HYPERTROPHIC CARDIOMYOPATHY ASSOCIATED WITH TACROLIMUS IN PEDIATRIC TRANSPLANT PATIENTS

被引：168

作者：

ATKISON, P ^{[1
]}

JOUBERT, G ^{[1
]}

BARRON, A ^{[1
]}

GRANT, D ^{[1
]}

PARADIS, K ^{[1
]}

SEIDMAN, E ^{[1
]}

WALL, W ^{[1
]}

ROSENBERG, H ^{[1
]}

HOWARD, J ^{[1
]}

WILLIAMS, S ^{[1
]}

STILLER, C ^{[1
]}

机构：

[1] UNIV MONTREAL,HOP ST JUSTINE,MONTREAL,PQ H3T 1C5,CANADA

来源：

LANCET | 1995年 / 345卷 / 8954期

关键词：

D O I：

10.1016/S0140-6736(95)90011-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.

引用

页码：894 / 896

页数：3

共 10 条

[1]

ABUELMAGD K, 1992, TRANSPLANT P, V24, P1243

[2] CONVERSION OF LIVER ALLOGRAFT RECIPIENTS FROM CYCLOSPORINE TO FK506 IMMUNOSUPPRESSIVE THERAPY - A CLINICOPATHOLOGICAL STUDY OF 96 PATIENTS [J].

DEMETRIS, AJ ;

FUNG, JJ ;

TODO, S ;

MCCAULEY, J ;

JAIN, A ;

TAKAYA, S ;

ALESSIANI, M ;

ABUELMAGD, K ;

VANTHIEL, DH ;

STARZL, TE .

TRANSPLANTATION, 1992, 53 (05) :1056-1062

[3]

MCCAULEY J, 1990, TRANSPLANT P, V22, P17

[4] A COMPARISON OF RENAL-FUNCTION IN CYCLOSPORINE-TREATED AND FK-506-TREATED PATIENTS AFTER PRIMARY ORTHOTOPIC LIVER-TRANSPLANTATION [J].

MCDIARMID, SV ;

COLONNA, JO ;

SHAKED, A ;

AMENT, ME ;

BUSUTTIL, RW .

TRANSPLANTATION, 1993, 56 (04) :847-853

[5]

Noto S, 1994, TRANSPLANT P, V26, P855

[6]

TEXTOR SC, 1993, TRANSPLANTATION, V55, P855

[7]

THIRU S, 1987, TRANSPLANT P, V19, P98

[8] PEDIATRIC LIVER-TRANSPLANTATION [J].

WHITINGTON, PF ;

ALONSO, EM ;

PIPER, JB .

SEMINARS IN LIVER DISEASE, 1994, 14 (03) :303-317

[9]

WIEDERRECHT G, 1994, ANN NY ACAD SCI, V696, P9

[10]

1994, LANCET, V344, P423

← 1 →