LOCALIZATION OF MODY3 TO A 5-CM REGION OF HUMAN-CHROMOSOME-12

被引：41

作者：

MENZEL, S

YAMAGATA, K

TRABB, JB

NERUP, J

PERMUTT, MA

FAJANS, SS

MENZEL, R

IWASAKI, N

OMORI, Y

COX, NJ

BELL, GI

机构：

[1] UNIV CHICAGO,HOWARD HUGHES MED INST,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

[4] STENO DIABET CTR,GENTOFTE,DENMARK

[5] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,DIV ENDOCRINOL DIABET & METAB,ST LOUIS,MO

[6] UNIV MICHIGAN,DEPT INTERNAL MED,DIV ENDOCRINOL & METAB,ANN ARBOR,MI 48109

[7] CLIN DIABET & METAB DIS,KARLSBURG,GERMANY

[8] TOKYO WOMENS MED COLL,CTR DIABET,TOKYO 162,JAPAN

来源：

DIABETES | 1995年 / 44卷 / 12期

关键词：

D O I：

10.2337/diabetes.44.12.1408

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maturity-onset diabetes of the young (MODY) is a heterogeneous disorder that appears to be characterized by a primary defect in insulin secretion, Mutations in an unknown locus (MODY1) on chromosome 20 and the glucokinase gene (MODY2) on chromosome 7 can cause this form of non-insulin-dependent diabetes. Recent genetic studies have identified a third locus on chromosome 12 (MODY3) that is linked to MODY in a group of French families, We have identified three families from Denmark, Germany, and the U.S. (Michigan) showing evidence of linkage with MODY3 and a family from Japan showing suggestive evidence. Analysis of key recombinants in these families localized MODY3 to a 5-cM interval between the markers D12S86 and D12S807/D12S820.

引用

页码：1408 / 1413

页数：6

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