IN-VITRO ANTIBACTERIAL ACTIVITY OF FUSIDIC ACID ALONE AND IN COMBINATION WITH OTHER ANTIBIOTICS AGAINST METHICILLIN-SENSITIVE AND METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

被引：23

作者：

DRUGEON, HB ^{[1
]}

CAILLON, J ^{[1
]}

JUVIN, ME ^{[1
]}

机构：

[1] CHU LAENNEC, BACTERIOL LAB B, NANTES, FRANCE

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1994年 / 34卷 / 06期

关键词：

D O I：

10.1093/jac/34.6.899

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activity of fusidic acid alone and in combination with gentamicin, oxacillin, rifampicin, fosfomycin and ciprofloxacin was investigated against 36 strains of Staphylococcus aureus. The fusidic acid MIC(50) of 0.06 mg/L and MIC(90) of 0.125 mg/L were determined for 36 strains. Bactericidal acitivity of fusidic acid was confirmed. Several types of interaction were observed with other antibiotics: dominant effect of fusidic acid over gentamicin; synergy with rifampicin for three or four strains; indifference or dominance with oxacillin, indifference with vancomycin, indifference or dominance with fosfomycin, and indifference with ciprofloxacin. Antagonism was seen with only one strain, following exposure to fusidic acid and rifampicin.

引用

页码：899 / 907

页数：9

共 24 条

[1] RESOLUTION OF CONFLICTING REPORTS CONCERNING MODE OF ACTION OF FUSIDIC ACID [J].