DIFFERENTIAL RXR AND RAR ACTIVITY OF STILBENE RETINOID ANALOGS BEARING THIAZOLE AND IMIDAZOLE CARBOXYLIC-ACIDS

被引：14

作者：

BEARD, RL ^{[1
]}

COLON, DF ^{[1
]}

KLEIN, ES ^{[1
]}

VORSE, KA ^{[1
]}

CHANDRARATNA, RAS ^{[1
]}

机构：

[1] ALLERGAN PHARMACEUT INC,DEPT BIOL,IRVINE,CA 92715

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 22期

关键词：

D O I：

10.1016/0960-894X(95)00455-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Retinoids are hormones which activate two distinct families of nuclear receptors: the retinoic acid receptors (RAR(alpha,beta,gamma)) and the retinoid X receptors (RXR(alpha,beta,gamma)). We report thiazole and imidazole substituted stilbene analogs that have RXR specific or pan-agonist activity and discuss the structural features that impart these differential activation properties to compounds of this class.

引用

页码：2729 / 2734

页数：6

共 36 条

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