A MAP KINASE NECESSARY FOR RECEPTOR-MEDIATED ACTIVATION OF ADENYLYL-CYCLASE IN DICTYOSTELIUM

被引:149
作者
SEGALL, JE [1 ]
KUSPA, A [1 ]
SHAULSKY, G [1 ]
ECKE, M [1 ]
MAEDA, M [1 ]
GASKINS, C [1 ]
FIRTEL, RA [1 ]
机构
[1] UNIV CALIF SAN DIEGO, CTR MOLEC GENET, DEPT BIOL, LA JOLLA, CA 92093 USA
关键词
D O I
10.1083/jcb.128.3.405
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.
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收藏
页码:405 / 413
页数:9
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共 69 条
  • [1] AHN NG, 1992, CIBA F SYMP, V164, P113
  • [2] BERKS M, 1991, DEVELOPMENT CAMB, V112, P131
  • [3] ERKS - A FAMILY OF PROTEIN-SERINE THREONINE KINASES THAT ARE ACTIVATED AND TYROSINE PHOSPHORYLATED IN RESPONSE TO INSULIN AND NGF
    BOULTON, TG
    NYE, SH
    ROBBINS, DJ
    IP, NY
    RADZIEJEWSKA, E
    MORGENBESSER, SD
    DEPINHO, RA
    PANAYOTATOS, N
    COBB, MH
    YANCOPOULOS, GD
    [J]. CELL, 1991, 65 (04) : 663 - 675
  • [4] A GAIN-OF-FUNCTION MUTATION IN DROSOPHILA MAP KINASE ACTIVATES MULTIPLE RECEPTOR TYROSINE KINASE SIGNALING PATHWAYS
    BRUNNER, D
    OELLERS, N
    SZABAD, J
    BIGGS, WH
    ZIPURSKY, SL
    HAFEN, E
    [J]. CELL, 1994, 76 (05) : 875 - 888
  • [5] CARROLL MP, 1994, J BIOL CHEM, V269, P1249
  • [6] NUCLEAR-LOCALIZATION AND REGULATION OF ERK-ENCODED AND RSK-ENCODED PROTEIN-KINASES
    CHEN, RH
    SARNECKI, C
    BLENIS, J
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (03) : 915 - 927
  • [7] CHILDS TJ, 1992, J BIOL CHEM, V267, P22853
  • [8] GROWING AND STARVING DICTYOSTELIUM CELLS PRODUCE DISTINCT DENSITY-SENSING FACTORS
    CLARKE, M
    DOMINGUEZ, N
    YUEN, IS
    GOMER, RH
    [J]. DEVELOPMENTAL BIOLOGY, 1992, 152 (02) : 403 - 406
  • [9] PATTERNING OF DEVELOPMENT IN DICTYOSTELIUM-DISCOIDEUM - FACTORS REGULATING GROWTH, DIFFERENTIATION, SPORE DORMANCY, AND GERMINATION
    COTTER, DA
    SANDS, TW
    VIRDY, KJ
    NORTH, MJ
    KLEIN, G
    SATRE, M
    [J]. BIOCHEMISTRY AND CELL BIOLOGY, 1992, 70 (10-11) : 892 - 919
  • [10] RAS-DEPENDENT ACTIVATION OF MAP KINASE PATHWAY MEDIATED BY G-PROTEIN BETA-GAMMA-SUBUNITS
    CRESPO, P
    XU, NZ
    SIMONDS, WF
    GUTKIND, JS
    [J]. NATURE, 1994, 369 (6479) : 418 - 420