Myocardial protection from ischemia-reperfusion injury post coronary revascularization

被引：169

作者：

Binder, Andrew ^{[1
]}

Ali, Asghar ^{[1
,2
]}

Chawla, Raveen ^{[1
]}

Aziz, Hammad A. ^{[1
]}

Abbate, Antonio ^{[1
]}

Jovin, Ion S. ^{[1
,2
]}

机构：

[1] Virginia Commonwealth Univ, Dept Med, Med Coll Virginia Campus, Richmond, VA 23298 USA

[2] Hunter Holmes McGuire Vet Affairs Med Ctr, Dept Med, Richmond, VA USA

来源：

EXPERT REVIEW OF CARDIOVASCULAR THERAPY | 2015年 / 13卷 / 09期

关键词：

acute myocardial infarction; cardiac surgery; ischemia-reperfusion injury; myocardial protection; percutaneous coronary intervention; postconditioning; preconditioning;

D O I：

10.1586/14779072.2015.1070669

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Effective primary and secondary prevention and advances in cardiac surgery have significantly improved the care and outcomes of patients with myocardial ischemia. While timely reperfusion has proved to be an invaluable tool, ischemia-reperfusion injury represents a mechanism that may limit its effectiveness. Numerous experimental studies have shown effective protection from ischemia-reperfusion injury in animal models, but translation into clinical practice has been less successful. This article summarizes the role of ischemia-reperfusion injury in the pathophysiology of ischemic heart disease and gives an overview of the various modalities that have been developed in order to provide myocardial protection from reperfusion injury in clinical practice.

引用

页码：1045 / 1057

页数：13

共 102 条

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