TRIAZENE DRUG METABOLITES - BASE-CATALYZED FORMATION OF N-ALKYLTRIAZENES FROM N-HYDROXYMETHYL-N-ALKYLTRIAZENES

被引：6

作者：

CHENG, SC ^{[1
]}

FERNADES, L ^{[1
]}

ILEY, J ^{[1
]}

ROSA, E ^{[1
]}

机构：

[1] OPEN UNIV,DEPT CHEM,MILTON KEYNES MK7 6AA,BUCKS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1985年 / 26卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)98551-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：1557 / 1560

页数：4

共 8 条

[1] EQUILIBRIA AND KINETICS OF N-HYDROXYMETHYLAMINE FORMATION FROM AROMATIC EXOCYCLIC AMINES AND FORMALDEHYDE - EFFECTS OF NUCLEOPHILICITY AND CATALYST STRENGTH UPON MECHANISMS OF CATALYSIS OF CARBINOLAMINE FORMATION [J].

ABRAMS, WR ;

KALLEN, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (24) :7777-7789

[2]

CHENG SC, 1983, J CHEM RES-S, P108

[3]

CHENG SC, 1983, J CHEM RES-S, P320

[4] OPEN-CHAIN NITROGEN-COMPOUNDS .5. HYDROXYMETHYLTRIAZENES - SYNTHESIS OF SOME NEW ALKYL HOMOLOGS OF THE ANTI-TUMOR 3-METHYL-3-HYDROXYMETHYLTRIAZENES AND PREPARATION OF THE DERIVED ACETOXYMETHYLTRIAZENES, BENZOYLOXYMETHYLTRIAZENES, AND METHOXYMETHYLTRIAZENES [J].

HEMENS, CM ;

MANNING, HW ;

VAUGHAN, K ;

LAFRANCE, RJ ;

TANG, Y .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1984, 62 (04) :741-748

[5] BIOLOGICAL PROPERTIES OF ANTI-TUMOR TRIAZENES [J].

JULLIARD, M ;

VERNIN, G .

INDUSTRIAL & ENGINEERING CHEMISTRY PRODUCT RESEARCH AND DEVELOPMENT, 1981, 20 (02) :287-296

[6] CARBINOLAMINES AND RELATED STRUCTURES - POTENTIAL ALKYLATING METABOLITES OF CLINICALLY ACTIVE ANTI-CANCER DRUGS [J].

SOLOWAY, AH ;

BRUMBAUGH, RJ ;

WITIAK, DT .

JOURNAL OF THEORETICAL BIOLOGY, 1983, 102 (03) :361-373

[7] STUDIES OF THE MODE OF ACTION OF ANTITUMOR TRIAZENES AND TRIAZINES .6. 1-ARYL-3-(HYDROXYMETHYL)-3-METHYLTRIAZENES - SYNTHESIS, CHEMISTRY, AND ANTITUMOR PROPERTIES [J].

VAUGHAN, K ;

TANG, Y ;

LLANOS, G ;

HORTON, JK ;

SIMMONDS, RJ ;

HICKMAN, JA ;

STEVENS, MFG .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (03) :357-363

[8] MONOALKYLTRIAZENES [J].

VAUGHAN, K ;

STEVENS, MFG .

CHEMICAL SOCIETY REVIEWS, 1978, 7 (03) :377-397

← 1 →