SOLUBLE INTERLEUKIN-2 RECEPTOR SECRETION DEFECT INVITRO IN HLA-B8, DR3 POSITIVE SUBJECTS

被引：14

作者：

MODICA, MA ^{[1
]}

DILORENZO, G ^{[1
]}

GALLUZZO, A ^{[1
]}

GIORDANO, C ^{[1
]}

PORTELLI, MR ^{[1
]}

CANDORE, G ^{[1
]}

CARUSO, C ^{[1
]}

机构：

[1] UNIV PALERMO,IST PATOL GEN,SERV IMMUNOL TISSUTALE,CORSO TUKORY 211,I-90134 PALERMO,ITALY

来源：

AUTOIMMUNITY | 1990年 / 7卷 / 2-3期

关键词：

Autoimmunity; HLA-BS.DR3; SlL-2R; T cells;

D O I：

10.3109/08916939008993381

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several studies have shown that HLA-B8,DR3 positive subjects may display T cell dysfunctions. Recently, a soluble form of the receptor for IL-2 (sIL-2R) has been demonstrated in human sera and in vitro-stimulat-ed culture supernatants from human T lymphocytes. In the present paper we report sIL-2R serum levels and sIL-2R production from peripheral blood mononuclear cells in HLA-B8,DR3 positive subjects. We found that HLA-B8.DR3 positive subjects have the highest values of serum sIL-2R. but comparing the values of these subjects with those of negative ones no significant difference was observed. As regards the in vitro production of sIL-ZR, no difference exists for unstimulated cultures, whereas after stimulation, the HLA-B8,DR3 positive subjects showed the lowest values compared with negative ones. It is noteworthy that these changes are observed in autoimmune diseases linked to this HLA phenotype. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：87 / 96

页数：10

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