THE STRENGTH AND PERIODICITY OF DROSOPHILA-MELANOGASTER CIRCADIAN-RHYTHMS ARE DIFFERENTIALLY AFFECTED BY ALTERATIONS IN PERIOD GENE-EXPRESSION

被引:50
作者
LIU, X [1 ]
YU, Q [1 ]
HUANG, Z [1 ]
ZWIEBEL, LJ [1 ]
HALL, JC [1 ]
ROSBASH, M [1 ]
机构
[1] BRANDEIS UNIV, DEPT BIOL, WALTHAM, MA 02254 USA
关键词
D O I
10.1016/0896-6273(91)90172-V
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The per gene of D. melanogaster influences or participates in the generation of biological rhythms. Previous experiments have identified the head as the location from which per exerts its effect on circadian rhythms. To localize further this region and to examine the effects of altered levels and altered spatial expression patterns of the per gene on circadian rhythms of locomotor activity, we have characterized transformed lines containing per gene constructs missing substantial cis-acting regulatory information. The data suggest that wild-type levels of per gene expression are necessary in only a small fraction of the nervous system for near wild-type periods, whereas a larger fraction of per-expressing cells in the brain contributes to the strength of the circadian rhythms.
引用
收藏
页码:753 / 766
页数:14
相关论文
共 46 条
[1]   CHANGES IN ABUNDANCE OR STRUCTURE OF THE PER GENE-PRODUCT CAN ALTER PERIODICITY OF THE DROSOPHILA CLOCK [J].
BAYLIES, MK ;
BARGIELLO, TA ;
JACKSON, FR ;
YOUNG, MW .
NATURE, 1987, 326 (6111) :390-392
[2]   REGULATION OF THE COMPLEX PATTERN OF SEVENLESS EXPRESSION IN THE DEVELOPING DROSOPHILA EYE [J].
BOWTELL, DDL ;
KIMMEL, BE ;
SIMON, MA ;
RUBIN, GM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6245-6249
[3]   INTRONS INCREASE TRANSCRIPTIONAL EFFICIENCY IN TRANSGENIC MICE [J].
BRINSTER, RL ;
ALLEN, JM ;
BEHRINGER, RR ;
GELINAS, RE ;
PALMITER, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (03) :836-840
[4]   REGULATORY ELEMENTS IN THE 1ST-INTRON CONTRIBUTE TO TRANSCRIPTIONAL REGULATION OF THE BETA-3 TUBULIN GENE BY 20-HYDROXYECDYSONE IN DROSOPHILA KC-CELLS [J].
BRUHAT, A ;
TOURMENTE, S ;
CHAPEL, S ;
SOBRIER, ML ;
COUDERC, JL ;
DASTUGUE, B .
NUCLEIC ACIDS RESEARCH, 1990, 18 (10) :2861-2867
[5]  
BUCHNER E, 1988, CELL TISSUE RES, V253, P357, DOI 10.1007/BF00222292
[6]   ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].
CHIRGWIN, JM ;
PRZYBYLA, AE ;
MACDONALD, RJ ;
RUTTER, WJ .
BIOCHEMISTRY, 1979, 18 (24) :5294-5299
[7]   A FAMILY OF UNUSUALLY SPLICED BIOLOGICALLY-ACTIVE TRANSCRIPTS ENCODED BY A DROSOPHILA CLOCK GENE [J].
CITRI, Y ;
COLOT, HV ;
JACQUIER, AC ;
QIANG, Y ;
HALL, JC ;
BALTIMORE, D ;
ROSBASH, M .
NATURE, 1987, 326 (6108) :42-47
[8]   BEHAVIOR OF INDIVIDUAL MATERNAL PA+ RNAS DURING EMBRYOGENESIS OF XENOPUS-LAEVIS [J].
COLOT, HV ;
ROSBASH, M .
DEVELOPMENTAL BIOLOGY, 1982, 94 (01) :79-86
[9]   CIRCADIAN-RHYTHMS IN DROSOPHILA-MELANOGASTER - ANALYSIS OF PERIOD AS A FUNCTION OF GENE DOSAGE AT THE PER (PERIOD) LOCUS [J].
COTE, GG ;
BRODY, S .
JOURNAL OF THEORETICAL BIOLOGY, 1986, 121 (04) :487-503
[10]   AN INDUCIBLE PROMOTER FUSED TO THE PERIOD GENE IN DROSOPHILA CONDITIONALLY RESCUES ADULT PER-MUTANT ARRHYTHMICITY [J].
EWER, J ;
ROSBASH, M ;
HALL, JC .
NATURE, 1988, 333 (6168) :82-84