SIMULTANEOUS MODELING OF PHARMACOKINETICS AND PHARMACODYNAMICS WITH NONPARAMETRIC KINETIC AND DYNAMIC-MODELS

被引:125
作者
UNADKAT, JD
BARTHA, F
SHEINER, LB
机构
[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT MED, DIV CLIN PHARMACOL, C255, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, SCH PHARM, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT PHARM, SAN FRANCISCO, CA 94143 USA
[4] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT LAB MED, SAN FRANCISCO, CA 94143 USA
关键词
D O I
10.1038/clpt.1986.143
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:86 / 93
页数:8
相关论文
共 21 条
[1]   A NOTE ON THE GENERATION OF RANDOM NORMAL DEVIATES [J].
BOX, GEP ;
MULLER, ME .
ANNALS OF MATHEMATICAL STATISTICS, 1958, 29 (02) :610-611
[2]   AN ANALYTICAL PHARMACODYNAMIC MODEL FOR NON-DEPOLARIZING NEUROMUSCULAR BLOCKING-AGENTS [J].
DHOLLANDER, A ;
DELCROIX, C .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1981, 9 (01) :27-40
[3]   ANALYTICAL MODEL OF SOME PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES OF FAZADINIUM IN MAN [J].
DHOLLANDER, AA ;
DELCROIX, C ;
DUVALDESTIN, P ;
HENZEL, D ;
COUSSAERT, E ;
DESMONTS, JM .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 24 (03) :407-413
[4]   PHARMACOKINETICS AND PHARMACODYNAMICS OF THE ANTIARRHYTHMIC COMPOUND MD750819 IN DOGS WITH EXPERIMENTALLY INDUCED ARRHYTHMIAS [J].
DOW, J ;
LAQUAIS, B ;
TISNEVERSAILLES, J ;
POURRIAS, B ;
BENEDETTI, MS .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1982, 10 (03) :283-296
[5]   VECURONIUM KINETICS AND DYNAMICS IN ANESTHETIZED INFANTS AND CHILDREN [J].
FISHER, DM ;
CASTAGNOLI, K ;
MILLER, RD .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (04) :402-406
[6]   SIMULTANEOUS MODELING OF PHARMACOKINETICS AND PHARMACODYNAMICS WITH A NONPARAMETRIC PHARMACODYNAMIC MODEL [J].
FUSEAU, E ;
SHEINER, LB .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 35 (06) :733-741
[7]   PHARMACODYNAMIC MEASUREMENTS OF METHYL NICOTINATE PERCUTANEOUS-ABSORPTION [J].
GUY, RH ;
TUR, E ;
BUGATTO, B ;
GAEBEL, C ;
SHEINER, LB ;
MAIBACH, HI .
PHARMACEUTICAL RESEARCH, 1984, (02) :76-81
[8]   INTEGRATED PHARMACOKINETICS AND PHARMACODYNAMICS OF ATROPINE IN HEALTHY HUMANS .2. PHARMACODYNAMICS [J].
HINDERLING, PH ;
GUNDERTREMY, U ;
SCHMIDLIN, O ;
HEINZEL, G .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (07) :711-717
[9]   THE EFFECT OF QUINIDINE AND ITS METABOLITES ON THE ELECTROCARDIOGRAM AND SYSTOLIC-TIME INTERVALS - CONCENTRATION - EFFECT RELATIONSHIPS [J].
HOLFORD, NHG ;
COATES, PE ;
GUENTERT, TW ;
RIEGELMAN, S ;
SHEINER, LB .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (02) :187-195
[10]   A MODEL FOR STUDYING DEPTH OF ANESTHESIA AND ACUTE TOLERANCE TO THIOPENTAL [J].
HUDSON, RJ ;
STANSKI, DR ;
SAIDMAN, LJ ;
MEATHE, E .
ANESTHESIOLOGY, 1983, 59 (04) :301-308