QUANTITATIVE AUTORADIOGRAPHIC STUDY ON TYROSINE-HYDROXYLASE MESSENGER-RNA WITH INSITU HYBRIDIZATION AND ALPHA-2-ADRENERGIC RECEPTOR-BINDING IN THE LOCUS-CERULEUS OF THE SPONTANEOUSLY HYPERTENSIVE RAT

被引：13

作者：

LUQUE, JM

GUILLAMON, A

HWANG, BH

机构：

[1] INDIANA UNIV,SCH MED,DEPT ANAT,TERRE HAUTE,IN 47809

[2] UNIV NACL EDUC DISTANCIA,DEPT PSYCHOBIOL,MADRID,SPAIN

来源：

NEUROSCIENCE LETTERS | 1991年 / 131卷 / 02期

关键词：

LOCUS-CERULEUS; HYPERTENSION; TYROSINE HYDROXYLASE MESSENGER RNA; INSITU HYBRIDIZATION; ALPHA-2 ADRENERGIC RECEPTOR;

D O I：

10.1016/0304-3940(91)90604-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alpha-2 Adrenergic (A2) receptors and tyrosine hydroxylase (TH) mRNA in the locus coeruleus (LC) were studied using [I-125]iodoclonidine and [S-35]TH oligonucleotide probe. Spontaneously hypertensive (SHR) rats contained less TH mRNA at their prehypertensive, but not at the well-established hypertensive stage, than age-matched Wistar-Kyoto rats. Furthermore, there is an up-regulation of A2 receptors in SHR rats which is parallel to their blood pressure elevation. The present data suggest that increased A2 receptors in conjunction with TH mRNA reduction in the LC are associated with initiation, but not maintenance of genetic hypertension.

引用

页码：163 / 166

页数：4

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