DOPAMINE-D1 ANTAGONISTS POTENTIATE THE DURATIONS OF BAR AND CLING CATALEPSY AND THE DORSAL IMMOBILITY RESPONSE IN RATS

被引：23

作者：

MEYER, ME

COTTRELL, GA

VANHARTESVELDT, C

机构：

[1] Department of Psychology, Center for Neurobiological Sciences, University of Florida, Gainesville

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 41卷 / 03期

关键词：

DOPAMINE-D1; ANTAGONIST; IMMOBILITY; SCH-23390; SK-AND-F-83566; RATS;

D O I：

10.1016/0091-3057(92)90365-M

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of dopamine D1 antagonists SCH 23390 or SK&F 83566 (at SC doses of 0.00, 0.01, 0.05, and 0.1 mg/kg) were tested for 2 h on bar and cling catalepsy and the dorsal immobility response. Each of the drugs potentiated the duration of each of the three measures of immobility in a dose- and time-dependent manner. Each of the drugs had rapid but brief effects on all three response measures; the peak effect of SK&F 83566 took place at 20 min and that for SCH 23390 at 40 min for each behavior. At each effective drug dose, SCH 23390 had a greater effect than SK&F 83566 on each behavior. Dopamine D1 antagonists potentiated three different immobility responses, as do dopamine D2 antagonists.

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页码：507 / 510

页数：4

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