DIFFUSION OF CEFPIROME INTO THE CEREBROSPINAL-FLUID OF PATIENTS WITH PURULENT-MENINGITIS

We evaluated the diffusion of cefpirome into the cerebrospinal fluid (CSF) of 25 patients with bacterial meningitis or ventriculitis who were receiving conventional antibiotic treatment A single cefpirome dose of 2 g was infused at day 2-3 after the onset of therapy. Concentrations of cefpirome in serum and CSF obtained at 2, 4, 8 or 12 h after the infusion were determined by high-performance liquid chromatography. The mean (±s.e.m.) concentrations of cefpirome in CSF ranged from 2-26± 116 to 417 ±083 mg/L. These concentrations were higher than the MBCs for the pathogens usually responsible for bacterial meningitis. © 1992 Oxford University Press.