COLLOIDAL MAGNETIC-RESONANCE CONTRAST AGENTS - EFFECT OF PARTICLE SURFACE ON BIODISTRIBUTION

被引：99

作者：

PAPISOV, MI ^{[1
]}

BOGDANOV, A ^{[1
]}

SCHAFFER, B ^{[1
]}

NOSSIFF, N ^{[1
]}

SHEN, T ^{[1
]}

WEISSLEDER, R ^{[1
]}

BRADY, TJ ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02129 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1993年 / 122卷 / 1-3期

关键词：

Iron oxides;

D O I：

10.1016/0304-8853(93)91115-N

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Surface structure of dextran-coated superparamagnetic particles is studied as a biodistribution-defining factor. Colloidal particle and polymer molecule of the same size and similar outer structure are shown to possess similar biokinetics and biodistribution. A dense dextran layer on the particle surface is identified as a structure responsible for particle accumulation in the lymph nodes.

引用

页码：383 / 386

页数：4

共 11 条

[1]

Bogdanov A. J., 1992, 1992 SOC MAGN RES ME, P864

[2] COLORIMETRIC METHOD FOR DETERMINATION OF SUGARS AND RELATED SUBSTANCES [J].