CROSS-REACTING SERUM OPSONINS IN PATIENTS WITH MENINGOCOCCAL DISEASE

被引：25

作者：

GUTTORMSEN, HK ^{[1
]}

BJERKNES, R ^{[1
]}

NAESS, A ^{[1
]}

LEHMANN, V ^{[1
]}

HALSTENSEN, A ^{[1
]}

SORNES, S ^{[1
]}

SOLBERG, CO ^{[1
]}

机构：

[1] UNIV BERGEN,HAUKELAND HOSP,DEPT PEDIAT,N-5021 BERGEN,NORWAY

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 07期

关键词：

D O I：

10.1128/IAI.60.7.2777-2783.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have examined the opsonic activity of sera from patients with Neisseria meningitidis (B:15:P1.16) infections against different meningococcal strains, using flow cytometry and luminol-enhanced chemiluminescence. A marked increase in the phagocytosis of ethanol-fixed meningococcal strains of different serogroups, serotypes, and serosubtypes was demonstrated in the presence of convalescence sera compared with acute sera. Convalescence sera also caused a significant increase of leukocyte oxidative metabolism during phagocytosis, as measured by luminol-enhanced chemiluminescence. The sera contained a broad range of opsonins cross-reacting with serogroup A, B, C, W-135, and Y meningococci of different serotypes and serosubtypes, indicating that the cross-reacting opsonins recognized surface epitopes other than those determined by current serotyping schemes.

引用

页码：2777 / 2783

页数：7

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