共 54 条
IN-VITRO ACTIVITIES OF PURIFIED VISNA VIRUS INTEGRASE
被引:30
作者:

KATZMAN, M
论文数: 0 引用数: 0
h-index: 0
机构:
PENN STATE UNIV,COLL MED,MILTON S HERSHEY MED CTR,DEPT MICROBIOL & IMMUNOL,HERSHEY,PA 17033 PENN STATE UNIV,COLL MED,MILTON S HERSHEY MED CTR,DEPT MICROBIOL & IMMUNOL,HERSHEY,PA 17033

SUDOL, M
论文数: 0 引用数: 0
h-index: 0
机构:
PENN STATE UNIV,COLL MED,MILTON S HERSHEY MED CTR,DEPT MICROBIOL & IMMUNOL,HERSHEY,PA 17033 PENN STATE UNIV,COLL MED,MILTON S HERSHEY MED CTR,DEPT MICROBIOL & IMMUNOL,HERSHEY,PA 17033
机构:
[1] PENN STATE UNIV,COLL MED,MILTON S HERSHEY MED CTR,DEPT MICROBIOL & IMMUNOL,HERSHEY,PA 17033
关键词:
D O I:
10.1128/JVI.68.6.3558-3569.1994
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Although integration generally is considered a critical step in the retrovirus life cycle, it has been reported that visna virus, which causes degenerative neurologic disease in sheep, can productively infect sheep choroid plexus cells without detectable integration. To ascertain whether the integrase (IN) of visna virus is an inherently defective enzyme and to create tools for further study of integration of the phylogenetically related human immunodeficiency virus type 1 (HIV-1), we purified visna virus IN by using a bacterial expression system and applied various in vitro oligonucleotide-based assays to studying this protein. We found that visna virus IN demonstrates the full repertoire of in vitro functions characteristic of retroviral integrases. In particular, visna virus IN exhibits site-specific endonuclease activity following the invariant CA found two nucleotides from the 3' ends of viral DNA (processing activity), joins processed oligonucleotides to various sites on other oligonucleotides (strand transfer or integration activity), and reverses the integration reaction by resolving a complex that mimics one end of viral DNA integrated into host DNA (disintegration activity). In addition, although it has been reported that purified HIV-1 IN cannot specifically nick visna virus DNA ends,purified visna virus IN does specifically process and integrate HIV-1 DNA ends.
引用
收藏
页码:3558 / 3569
页数:12
相关论文
共 54 条
- [1] NUCLEOTIDE-SEQUENCE AND BIOLOGICAL PROPERTIES OF A PATHOGENIC PROVIRAL MOLECULAR CLONE OF NEUROVIRULENT VISNA VIRUS[J]. VIROLOGY, 1993, 193 (01) : 89 - 105ANDRESSON, OS论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAELSER, JE论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USATOBIN, GJ论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAGREENWOOD, JD论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAGONDA, MA论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAGEORGSSON, G论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAANDRESDOTTIR, V论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USABENEDIKTSDOTTIR, E论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USACARLSDOTTIR, HM论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAMANTYLA, EO论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USARAFNAR, B论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAPALSSON, PA论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USACASEY, JW论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USAPETURSSON, G论文数: 0 引用数: 0 h-index: 0机构: NCI, FREDERICK CANC RES & DEV CTR, PROGRAM RESOURCES INC DYNCORP, CELL & MOLEC STRUCT LAB, FREDERICK, MD 21702 USA
- [2] A NUCLEOPROTEIN COMPLEX MEDIATES THE INTEGRATION OF RETROVIRAL DNA[J]. GENES & DEVELOPMENT, 1989, 3 (04) : 469 - 478BOWERMAN, B论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143BROWN, PO论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143BISHOP, JM论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143VARMUS, HE论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT MICROBIOL & IMMUNOL,SAN FRANCISCO,CA 94143
- [3] THE VISNA VIRUS GENOME - EVIDENCE FOR A HYPERVARIABLE SITE IN THE ENV-GENE AND SEQUENCE HOMOLOGY AMONG LENTIVIRUS ENVELOPE PROTEINS[J]. JOURNAL OF VIROLOGY, 1987, 61 (12) : 4046 - 4054BRAUN, MJ论文数: 0 引用数: 0 h-index: 0机构: NCI,FREDERICK CANC RES FACIL,PROGRAM RESOURCES INC,CELL & MOLEC STRUCT LAB,FREDERICK,MD 21701CLEMENTS, JE论文数: 0 引用数: 0 h-index: 0机构: NCI,FREDERICK CANC RES FACIL,PROGRAM RESOURCES INC,CELL & MOLEC STRUCT LAB,FREDERICK,MD 21701GONDA, MA论文数: 0 引用数: 0 h-index: 0机构: NCI,FREDERICK CANC RES FACIL,PROGRAM RESOURCES INC,CELL & MOLEC STRUCT LAB,FREDERICK,MD 21701
- [4] RETROVIRAL INTEGRATION - STRUCTURE OF THE INITIAL COVALENT PRODUCT AND ITS PRECURSOR, AND A ROLE FOR THE VIRAL IN PROTEIN[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2525 - 2529BROWN, PO论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,GW HOOPER RES FDN,SAN FRANCISCO,CA 94143BOWERMAN, B论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,GW HOOPER RES FDN,SAN FRANCISCO,CA 94143VARMUS, HE论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,GW HOOPER RES FDN,SAN FRANCISCO,CA 94143BISHOP, JM论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,GW HOOPER RES FDN,SAN FRANCISCO,CA 94143
- [5] DOMAINS OF THE INTEGRASE PROTEIN OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RESPONSIBLE FOR POLYNUCLEOTIDYL TRANSFER AND ZINC-BINDING[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) : 3428 - 3432BUSHMAN, FD论文数: 0 引用数: 0 h-index: 0机构: NIDDKD, MOLEC BIOL LAB, BETHESDA, MD 20892 USAENGELMAN, A论文数: 0 引用数: 0 h-index: 0机构: NIDDKD, MOLEC BIOL LAB, BETHESDA, MD 20892 USAPALMER, I论文数: 0 引用数: 0 h-index: 0机构: NIDDKD, MOLEC BIOL LAB, BETHESDA, MD 20892 USAWINGFIELD, P论文数: 0 引用数: 0 h-index: 0机构: NIDDKD, MOLEC BIOL LAB, BETHESDA, MD 20892 USACRAIGIE, R论文数: 0 引用数: 0 h-index: 0机构: NIDDKD, MOLEC BIOL LAB, BETHESDA, MD 20892 USA
- [6] ACTIVITIES OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INTEGRATION PROTEIN INVITRO - SPECIFIC CLEAVAGE AND INTEGRATION OF HIV DNA[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1339 - 1343BUSHMAN, FD论文数: 0 引用数: 0 h-index: 0CRAIGIE, R论文数: 0 引用数: 0 h-index: 0
- [7] REVERSAL OF INTEGRATION AND DNA SPLICING MEDIATED BY INTEGRASE OF HUMAN-IMMUNODEFICIENCY-VIRUS[J]. SCIENCE, 1992, 255 (5045) : 723 - 726CHOW, SA论文数: 0 引用数: 0 h-index: 0机构: STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305VINCENT, KA论文数: 0 引用数: 0 h-index: 0机构: STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305ELLISON, V论文数: 0 引用数: 0 h-index: 0机构: STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305BROWN, PO论文数: 0 引用数: 0 h-index: 0机构: STANFORD UNIV,MED CTR,DEPT PEDIAT,STANFORD,CA 94305
- [8] OVERLAPPING RETROVIRUS U5 SEQUENCE ELEMENTS ARE REQUIRED FOR EFFICIENT INTEGRATION AND INITIATION OF REVERSE TRANSCRIPTION[J]. JOURNAL OF VIROLOGY, 1991, 65 (07) : 3864 - 3872COBRINIK, D论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106AIYAR, A论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106GE, Z论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106KATZMAN, M论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106HUANG, H论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106LEIS, J论文数: 0 引用数: 0 h-index: 0机构: CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT BIOCHEM,CLEVELAND,OH 44106
- [9] THE IN PROTEIN OF MOLONEY MURINE LEUKEMIA-VIRUS PROCESSES THE VIRAL-DNA ENDS AND ACCOMPLISHES THEIR INTEGRATION INVITRO[J]. CELL, 1990, 62 (04) : 829 - 837CRAIGIE, R论文数: 0 引用数: 0 h-index: 0机构: Laboratory of Molecular Biology National Inst. of Diabetes and Digestive and Kidney Diseases BethesdFUJIWARA, T论文数: 0 引用数: 0 h-index: 0机构: Laboratory of Molecular Biology National Inst. of Diabetes and Digestive and Kidney Diseases BethesdBUSHMAN, F论文数: 0 引用数: 0 h-index: 0机构: Laboratory of Molecular Biology National Inst. of Diabetes and Digestive and Kidney Diseases Bethesd
- [10] IDENTIFICATION OF AMINO-ACID-RESIDUES CRITICAL FOR ENDONUCLEASE AND INTEGRATION ACTIVITIES OF HIV-1 IN PROTEIN INVITRO[J]. VIROLOGY, 1992, 188 (02) : 459 - 468DRELICH, M论文数: 0 引用数: 0 h-index: 0机构: F HOFFMANN LA ROCHE & CO LTD, DEPT BIOL, CH-4002 BASEL, SWITZERLAND F HOFFMANN LA ROCHE & CO LTD, DEPT BIOL, CH-4002 BASEL, SWITZERLANDWILHELM, R论文数: 0 引用数: 0 h-index: 0机构: F HOFFMANN LA ROCHE & CO LTD, DEPT BIOL, CH-4002 BASEL, SWITZERLAND F HOFFMANN LA ROCHE & CO LTD, DEPT BIOL, CH-4002 BASEL, SWITZERLANDMOUS, J论文数: 0 引用数: 0 h-index: 0机构: F HOFFMANN LA ROCHE & CO LTD, DEPT BIOL, CH-4002 BASEL, SWITZERLAND F HOFFMANN LA ROCHE & CO LTD, DEPT BIOL, CH-4002 BASEL, SWITZERLAND