PH-DEPENDENT HYDROLYSIS AND DRUG-RELEASE OF CHITOSAN POLYETHER INTERPENETRATING POLYMER NETWORK HYDROGEL

被引：45

作者：

YAO, KD

PENG, T

XU, MX

YUAN, C

GOOSEN, MFA

ZHANG, QQ

REN, L

机构：

[1] QUEENS UNIV,DEPT CHEM ENGN,KINGSTON K7L 3N6,ONTARIO,CANADA

[2] CHINESE ACAD MED SCI,INST BIOMED ENGN,TIANJIN 300192,PEOPLES R CHINA

来源：

POLYMER INTERNATIONAL | 1994年 / 34卷 / 02期

关键词：

HYDROLYSIS; DRUG RELEASE; IPN; GEL; SWELLING;

D O I：

10.1002/pi.1994.210340213

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This paper describes a novel hydrogel based on crosslinked chitosan with glutaraldehyde interpenetrating polyether polymer network. The gel can hydrolyse in acid at 37-degrees-C due to the cleavage of imine bonds within the network. At pH greater-than-or-equal-to 7, there is no hydrolysis. The pH-dependent release of cimetidine from the gel was also investigated.

引用

页码：213 / 219

页数：7

共 38 条

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