EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR (FGF-2) MESSENGER-RIBONUCLEIC-ACID IS REGULATED BY TESTOSTERONE IN THE RAT ANTERIOR-PITUITARY

被引：8

作者：

YOSHIMURA, K

KAJI, H

KAMIDONO, S

CHIHARA, K

机构：

[1] KOBE UNIV,SCH MED,DIV METAB,KOBE 650,JAPAN

[2] KOBE UNIV,SCH MED,DEPT MED,DIV 3,KOBE 650,JAPAN

来源：

GROWTH FACTORS | 1994年 / 10卷 / 04期

关键词：

BASIC FIBROBLAST GROWTH FACTOR (FGF-2); MESSENGER-RNA; ANTERIOR PITUITARY; TESTOSTERONE; RNASE PROTECTION ANALYSIS;

D O I：

10.3109/08977199409010991

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Evidence from in vitro studies supports the concept that growth factors are involved in the function of endocrine organs. We studied the effects of target endocrine organs (thyroid, adrenals, and gonads) on levels of basic fibroblast growth factor (FGF-2) messenger ribonucleic acid (mRNA) in the anterior pituitary and the hypothalamus of male rats using RNase protection assays. Castration significantly reduced the levels of FGF-2 mRNA in the anterior pituitary, but not in the hypothalamus. This decrease was restored by testosterone administration. The regulation of pituitary FGF-2 mRNA involves a specific hormone, i.e. testosterone, since neither adrenalectomy nor chemical thyroidectomy affects the expression of the gene for FGF-2.

引用

收藏

页码：253 / 258

页数：6

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