THE CELLULAR MYB ONCOGENE IS AMPLIFIED, REARRANGED AND ACTIVATED IN HUMAN GLIOBLASTOMA CELL-LINES

被引：36

作者：

WELTER, C

HENN, W

THEISINGER, B

FISCHER, H

ZANG, KD

BLIN, N

机构：

[1] UNIV SAARLAND,SCH MED,DEPT HUMAN GENET,W-6650 HOMBURG,GERMANY

[2] GERMAN CANC RES CTR,INST VIROL,W-6900 HEIDELBERG,GERMANY

来源：

CANCER LETTERS | 1990年 / 52卷 / 01期

关键词：

amplification; carcinogenesis; neurogenic tumor; overexpression; proto-oncogene;

D O I：

10.1016/0304-3835(90)90077-B

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by densitometry was about 10-fold, a rearrangement within the coding region and an enhanced gene activity of c-myb were noted. The observation of c-myb oncogene amplification and activity in glioblastoma cell lines presents the first report of this effect in human brain tumor cells. © 1990.

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页码：57 / 62

页数：6

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