THE VIRAL ERBA ONCOGENE PROTEIN, A CONSTITUTIVE REPRESSOR IN ANIMAL-CELLS, IS A HORMONE-REGULATED ACTIVATOR IN YEAST

被引:84
作者
PRIVALSKY, ML [1 ]
SHARIF, M [1 ]
YAMAMOTO, KR [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/0092-8674(90)90423-C
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The v-erbA oncogene is a retrovirus-transduced and altered copy of a cellular gene for a thyroid hormone receptor. In animal cells, the v-erbA protein fails to respond to hormone and acts as a dominant negative allele, inhibiting gene activation normally conferred by the wild-type thyroid hormone receptor. We report here that, unexpectedly, the v-erbA protein acts as a hormone-regulated transcriptional activator in S. cerevisiae. We suggest that the ability of v-erbA protein to function as a transcriptional repressor or an activator is determined by interaction with, or modification by, other cellular factors, and that this phenomenon may be relevant to understanding ligand regulation of the normal thyroid and steroid hormone receptors.
引用
收藏
页码:1277 / 1286
页数:10
相关论文
共 48 条
[1]   NEGATIVE REGULATION BY GLUCOCORTICOIDS THROUGH INTERFERENCE WITH A CAMP RESPONSIVE ENHANCER [J].
AKERBLOM, IE ;
SLATER, EP ;
BEATO, M ;
BAXTER, JD ;
MELLON, PL .
SCIENCE, 1988, 241 (4863) :350-353
[2]   GENE-REGULATION BY STEROID-HORMONES [J].
BEATO, M .
CELL, 1989, 56 (03) :335-344
[3]   FUSION OF ADENOVIRUS E1A TO THE GLUCOCORTICOID RECEPTOR BY HIGH-RESOLUTION DELETION CLONING CREATES A HORMONALLY INDUCIBLE VIRAL TRANSACTIVATOR [J].
BECKER, DM ;
HOLLENBERG, SM ;
RICCIARDI, RP .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) :3878-3887
[4]   SEQUENCE-SPECIFIC DNA-BINDING BY THE V-ERBA ONCOGENE PROTEIN OF AVIAN ERYTHROBLASTOSIS VIRUS [J].
BONDE, BG ;
PRIVALSKY, ML .
JOURNAL OF VIROLOGY, 1990, 64 (03) :1314-1320
[5]  
BOUCHER P, 1990, ONCOGENE, V5, P1303
[6]  
BRESNICK EH, 1989, J BIOL CHEM, V264, P4992
[7]  
DALMAN FC, 1990, J BIOL CHEM, V265, P3615
[8]   PROTEIN ENCODED BY V-ERBA FUNCTIONS AS A THYROID-HORMONE RECEPTOR ANTAGONIST [J].
DAMM, K ;
THOMPSON, CC ;
EVANS, RM .
NATURE, 1989, 339 (6226) :593-597
[9]  
DENIS M, 1989, CANCER RES, V49, pS2275
[10]   TRANSCRIPTION FACTOR INTERACTIONS - SELECTORS OF POSITIVE OR NEGATIVE REGULATION FROM A SINGLE DNA ELEMENT [J].
DIAMOND, MI ;
MINER, JN ;
YOSHINAGA, SK ;
YAMAMOTO, KR .
SCIENCE, 1990, 249 (4974) :1266-1272