A NOVEL REPEATED DNA-SEQUENCE LOCATED IN THE INTERGENIC REGIONS OF BACTERIAL CHROMOSOMES

被引：164

作者：

SHARPLES, GJ

LLOYD, RG

机构：

[1] Department of Genetics, University of Nottingham, Medical School, Queens Medical Centre, Nottingham

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 22期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/nar/18.22.6503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the discovery of a novel group of highly conserved DNA sequences located within the intergenic regions of the chromosomes of Escherichia coll, Salmonella typhimurium and other bacteria. These intergenic repeat units (IRUs) are 124-127 nucleotides long and have the potential to form stable stem-loop structures. The location of these sequences within the intergenic regions is variable with respect to known or putative signals for transcription and translation of the flanking genes. Some of the IRU sequences are transcribed, others are probably not. The structure and possible functions of these sequences are discussed in relation to palindromic units and other repeated DNA sequences in bacteria. © 1990 Oxford University Press.

引用

页码：6503 / 6508

页数：6

共 48 条

[1] IDENTIFICATION, MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF A GENE-CLUSTER ENCODING THE CLASS-II FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE, 3-PHOSPHOGLYCERATE KINASE AND A PUTATIVE 2ND GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE OF ESCHERICHIA-COLI [J].