SYNTHESIS AND BIOLOGICAL-ACTIVITY OF MK-287 (L-680,573) - A POTENT, SPECIFIC AND ORALLY ACTIVE PAF RECEPTOR ANTAGONIST

被引：25

作者：

SAHOO, SP

GRAHAM, DW

ACTON, J

BIFTU, T

BUGIANESI, RL

GIROTRA, NN

KUO, CH

PONPIPOM, MM

DOEBBER, TW

WU, MS

HWANG, SB

LAM, MH

MACINTYRE, DE

BACH, TJ

LUELL, S

MEURER, R

DAVIES, P

ALBERTS, AW

CHABALA, JC

机构：

[1] Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80818-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An enantioselective synthesis of MK 287 (L-680,573), a member of a family of trans-2,5-diaryltetrahydrofurans, and its biological activity are described.

引用

页码：327 / 332

页数：6

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