MIXED CONNECTIVE-TISSUE DISEASE ASSOCIATED WITH PROTEIN LOSING ENTEROPATHY - SUCCESSFUL TREATMENT WITH INTRAVENOUS CYCLOPHOSPHAMIDE THERAPY

被引：12

作者：

FURUYA, T ^{[1
]}

SUZUKI, T ^{[1
]}

ONODA, N ^{[1
]}

TAMURA, K ^{[1
]}

SATO, K ^{[1
]}

DEMURA, H ^{[1
]}

KASHIWAZAKI, S ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,DEPT INTERNAL MED 2,TOKYO 162,JAPAN

来源：

INTERNAL MEDICINE | 1992年 / 31卷 / 12期

关键词：

CYCLOPHOSPHAMIDE PULSE THERAPY; CA125; ANTIGEN;

D O I：

10.2169/internalmedicine.31.1359

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with mixed connective tissue disease who developed protein losing enteropathy (PLE) is described. The PLE and other symptoms improved dramatically after monthly intravenous administration of 700 mg/day cyclophosphamide three times combined with oral prednisolone, while they were ineffective to the treatment with intravenous methyl-prednisolone 500 mg per day for 3 days. The serum level of CA125 antigen paralleled the severity of symptoms, signs and laboratory data associated with PLE. Thus, pleural effusion, ascites, edema and hypoalbuminemia improved along with the decrease in the level of CA125, suggesting that CA125 might be a marker of the activity of PLE.

引用

页码：1359 / 1362

页数：4