THE INTERACTION OF NATURALLY ELABORATED BLEBS FROM SERUM-SUSCEPTIBLE AND SERUM-RESISTANT STRAINS OF NEISSERIA-GONORRHOEAE WITH NORMAL HUMAN SERUM

被引：39

作者：

PETTIT, RK ^{[1
]}

JUDD, RC ^{[1
]}

机构：

[1] UNIV MONTANA,DIV BIOL SCI,MISSOULA,MT 59812

来源：

MOLECULAR MICROBIOLOGY | 1992年 / 6卷 / 06期

关键词：

D O I：

10.1111/j.1365-2958.1992.tb01522.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied the interaction of normal human serum immunoglobulins with outer-membrane bleb antigens of Neisseria gonorrhoeae. Gonococcal 68 000 Dalton and Lip (H.8 antigen) outer-membrane proteins were recognized by normal human serum immunoglobulins in blebs from serum-resistant strains, but not in blebs from serum-susceptible strains. The addition of blebs from a serum-resistant strain to bactericidal assays resulted in significantly greater inhibition of serum killing than the addition of blebs from a serum-susceptible strain. Our results indicate that blebs from two serum-resistant gonococcal strains have an enhanced ability to bind and remove cell-targeted bactericidal factors, and that outer-membrane blebbing may contribute to serum resistance.

引用

页码：729 / 734

页数：6

共 39 条

[1] EVIDENCE FOR A MEMBRANE-BOUND FORM OF A BACTERIOCIN OF BACTEROIDES-UNIFORMIS TL-1 [J].