VOLTAMMETRIC DETERMINATION OF THE ANTIDEPRESSANT TRIMIPRAMINE AT A LIPID-MODIFIED CARBON-PASTE ELECTRODE

被引：21

作者：

KHODARI, M

机构：

[1] Chemistry Department, Faculty of Science, Kena

来源：

ELECTROANALYSIS | 1993年 / 5卷 / 5-6期

关键词：

TRIMIPRAMINE ANALYSIS; VOLTAMMETRY; CARBON PASTE ELECTRODE; MODIFIED ELECTRODES;

D O I：

10.1002/elan.1140050523

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The voltammetric behavior of trimipramine at a carbon paste electrode (CPE) modified with some fatty acids is investigated. This hydrophobic drug is accumulated at the electrode by a combined adsorption/extraction process, with greatly enhanced response over the unmodified paste. The linear-scan response was characterized with respect to preconcentration period, pH, paste composition, reproducibility, possible interferences, and other variables. The detection limit was found to be 1 x 10(-9) M. The determination of trimipramine in urine required no pretreatment other than dilution with phosphate buffer and medium exchange technique.

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页码：521 / 523

页数：3

相关论文

共 17 条

[1] VOLTAMMETRIC DETERMINATION OF DOXORUBICIN IN URINE BY ADSORPTIVE PRECONCENTRATION AND FLOW-INJECTION ANALYSIS [J].

CHANEY, EN ;

BALDWIN, RP .

ANALYTICA CHIMICA ACTA, 1985, 176 (OCT) :105-112

[2] APPLICATIONS OF CHEMICALLY MODIFIED ELECTRODES TO ANALYSIS OF METAL-IONS [J].

CHEEK, GT ;

NELSON, RF .

ANALYTICAL LETTERS, 1978, 11 (05) :393-402

[3] PRE-CONCENTRATION OF PHENANTHRENEQUINONE-LIKE COMPOUNDS FOR ELECTROCHEMICAL DETERMINATION AT A CARBON PASTE ELECTRODE VIA SPONTANEOUS ADSORPTION [J].

CHENG, HY ;

FALAT, L ;

LI, RL .

ANALYTICAL CHEMISTRY, 1982, 54 (08) :1384-1388

[4] ANTHRACYCLINE GLYCOSIDE-MEMBRANE INTERACTIONS [J].

GOORMAGHTIGH, E ;

RUYSSCHAERT, JM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 779 (03) :271-288

[5] DETERMINATION OF MERCURY(II) USING A MODIFIED ELECTRODE WITH ZEOLITE [J].

HERNANDEZ, P ;

ALDA, E ;

HERNANDEZ, L .

FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1987, 327 (07) :676-678

[6] PRE-CONCENTRATION OF CHLORPROMAZINE AT A WAX-IMPREGNATED GRAPHITE ELECTRODE [J].

JARBAWI, TB ;

HEINEMAN, WR .

ANALYTICA CHIMICA ACTA, 1982, 135 (02) :359-362

[7] PRECONCENTRATION OF TRANQUILIZERS BY ADSORPTION EXTRACTION AT A WAX-IMPREGNATED GRAPHITE ELECTRODE [J].

JARBAWI, TB ;

HEINEMAN, WR .

ANALYTICA CHIMICA ACTA, 1986, 186 :11-19

[8] CHEMICALLY MODIFIED CARBON PASTE ELECTRODES IN VOLTAMMETRIC ANALYSIS [J].

KALCHER, K .

ELECTROANALYSIS, 1990, 2 (06) :419-433

[9] PRECONCENTRATION AND DETERMINATION OF PROMETHAZINE AT LIPID-MODIFIED CARBON PASTE ELECTRODES [J].

KHODARI, M ;

KAUFFMANN, JM ;

PATRIARCHE, GJ ;

GHANDOUR, MA .

ELECTROANALYSIS, 1989, 1 (06) :501-505

[10] APPLICATIONS IN DRUG ANALYSIS OF CARBON PASTE ELECTRODES MODIFIED BY FATTY-ACIDS [J].

KHODARI, M ;

KAUFFMANN, JM ;

PATRIARCHE, GJ ;

GHANDOUR, MA .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1989, 7 (12) :1491-1497