AGING OF HUMAN ERYTHROCYTES - DIFFERENTIAL SENSITIVITY OF YOUNG AND OLD ERYTHROCYTES TO HEMOLYSIS INDUCED BY PEROXIDE IN PRESENCE OF THYROXINE

被引：57

作者：

WALLS, R ^{[1
]}

KUMAR, KS ^{[1
]}

HOCHSTEIN, P ^{[1
]}

机构：

[1] UNIV SO CALIF, SCH MED, DEPT PHARMACOL, LOS ANGELES, CA 90033 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1976年 / 174卷 / 02期

关键词：

D O I：

10.1016/0003-9861(76)90374-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human erythrocytes were separated according to cell age using albumin density gradients. In the presence of glucose (100 mg%), young cells were able to effectively protect themselves against thyroxine-peroxide induced hemolysis; old cells exhibited less protection. Hemolysis in heterogeneous populations was preceded by lipid peroxidation, K+ leak and decreased filtrability of the cells. Hydroxy radical scavengers partially inhibited hemolysis while superoxide dismutase had no effect. The differential sensitivity of young and old erythrocytes to thyroxine-peroxide induced metabolic and morphological alterations may play a role in the recognition and removal of senescent cells from the circulation.

引用

页码：463 / 468

页数：6

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