NOVEL AVERMECTINS PRODUCED BY MUTATIONAL BIOSYNTHESIS

被引：137

作者：

DUTTON, CJ ^{[1
]}

GIBSON, SP ^{[1
]}

GOUDIE, AC ^{[1
]}

HOLDOM, KS ^{[1
]}

PACEY, MS ^{[1
]}

RUDDOCK, JC ^{[1
]}

BULOCK, JD ^{[1
]}

RICHARDS, MK ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT CHEM,WEIZMANN MICROBIAL LAB,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 03期

关键词：

D O I：

10.7164/antibiotics.44.357

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.

引用

页码：357 / 365

页数：9

共 26 条

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