WHAT DRIVES THE TRANSLOCATION OF PROTEINS

被引：373

作者：

SIMON, SM

PESKIN, CS

OSTER, GF

机构：

[1] NYU,COURANT INST MATH SCI,NEW YORK,NY 10012

[2] UNIV CALIF BERKELEY,DEPT MOLEC & CELLULAR BIOL,BERKELEY,CA 94720

[3] UNIV CALIF BERKELEY,DEPT ENTOMOL,BERKELEY,CA 94720

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 09期

关键词：

BROWNIAN MOTION; HEAT SHOCK PROTEINS; CHAPERONINS; MODEL;

D O I：

10.1073/pnas.89.9.3770

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose that protein translocation across membranes is driven by biased random thermal motion. This "Brownian ratchet" mechanism depends on chemical asymmetries between the cis and trans sides of the membrane. Several mechanisms could contribute to rectifying the thermal motion of the protein, such as binding and dissociation of chaperonins to the translocating chain, chain coiling induced by pH and/or ionic gradients, glycosylation, and disulfide bond formation. This helps explain the robustness and promiscuity of these transport systems.

引用

页码：3770 / 3774

页数：5

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