AGE-RELATED CHANGE IN THE VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NEURONS IN THE CEREBRAL-CORTEX OF AGED RATS

被引：6

作者：

CHA, CI ^{[1
]}

LEE, EY ^{[1
]}

LEE, YI ^{[1
]}

BAIK, SH ^{[1
]}

机构：

[1] CHUNGBUK NATL UNIV, COLL MED, DEPT ANAT, CHUNGBUK, SOUTH KOREA

来源：

NEUROSCIENCE LETTERS | 1995年 / 197卷 / 01期

关键词：

VASOACTIVE INTESTINAL POLYPEPTIDE; CEREBRAL CORTEX; AGED RAT; LOSS OF NEURONS; IRREGULAR ORIENTATION; IMMUNOCYTOCHEMISTRY;

D O I：

10.1016/0304-3940(95)11897-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have explored certain changes in neurons containing neuropeptide with aging. However, until now, the degree of vasoactive intestinal polypeptide (VIP)-containing neuronal cell loss in the aged CNS has not yet been established with certainty, and available data are often contradictory. Changes in the VIP-containing neurons with aging were demonstrated by immunocytochemistry. Major loss of VIP-immunoreactive neurons in the aged rat brain were observed in frontal cortex area 3, parietal cortex area 1, hindlimb area, temporal cortex area 1 and 2, monocular part of occipital cortex area, 1, occipital cortex area 2, and retrosplenial cortex. Frontal cortex area 1 and 2, parietal cortex area 2, forelimb area, binocular part of the occipital cortex area 1, and the dentate gyrus were moderately decreased. The axis of the VIP neurons in the aged group showed an irregular orientation tendency, especially in layers II and III. These results indicate the involvement of a neuronal system containing VIP in the aging brain, and provide the first morphological evidence for the loss of VIP neurons in the cerebral cortex of the aged rat.

引用

页码：45 / 48

页数：4

共 25 条

[1]

ALEXANDER P, 1994, NEUROBIOL AGING, V15, P589

[2] SOMATOSTATIN AND VASOACTIVE INTESTINAL POLYPEPTIDE IN POSTMORTEM BRAINS FROM PATIENTS WITH ALZHEIMER-TYPE DEMENTIA [J].

ARAI, H ;

MOROJI, T ;

KOSAKA, K .

NEUROSCIENCE LETTERS, 1984, 52 (1-2) :73-78

[3]

BUETOW DE, 1985, CRC HDB CELL BIOL AG, P1

[4]

BURKS TF, 1981, AGE, V4, P143

[5]

COLEMAN PD, 1987, NEUROBIOL AGING, V8, P521, DOI 10.1016/0197-4580(87)90127-8

[6]

CURCIO CA, 1981, ADV NEUROGERONTOLOGY, V3, P7

[7] ABNORMALITIES IN CORTICOTROPIN-RELEASING HORMONE (CRH) IN ALZHEIMERS-DISEASE AND OTHER HUMAN DISORDERS [J].

DESOUZA, EB ;

WHITEHOUSE, PJ ;

PRICE, DL ;

VALE, WW .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 512 :237-247

[8] NEUROPEPTIDES IN ALZHEIMER TYPE DEMENTIA [J].

FERRIER, IN ;

CROSS, AJ ;

JOHNSON, JA ;

ROBERTS, GW ;

CROW, TJ ;

CORSELLIS, JAN ;

LEE, YC ;

OSHAUGHNESSY, D ;

ADRIAN, TE ;

MCGREGOR, GP ;

BARACESEHAMILTON, AJ ;

BLOOM, SR .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1983, 62 (1-3) :159-170

[9] THE VASOPRESSIN AND OXYTOCIN NEURONS IN THE HUMAN SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS - CHANGES WITH AGING AND IN SENILE DEMENTIA [J].

FLIERS, E ;

SWAAB, DF ;

POOL, CW ;

VERWER, RWH .

BRAIN RESEARCH, 1985, 342 (01) :45-53

[10] ACTIVATION OF VASOPRESSINERGIC AND OXYTOCINERGIC NEURONS DURING AGING IN THE WISTAR RAT [J].

FLIERS, E ;

SWAAB, DF .

PEPTIDES, 1983, 4 (02) :165-170

← 1 2 3 →