SUPEROXIDE-DISMUTASE INHIBITS INTERLEUKIN-1-INDUCED DEGRADATION OF HUMAN CARTILAGE

被引：24

作者：

FUKUDA, K

DAN, H

SAITOH, M

TAKAYAMA, M

TANAKA, S

机构：

[1] Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka-sayama, Osaka, 589, 377-2, Ohno-higashi

来源：

AGENTS AND ACTIONS | 1994年 / 42卷 / 1-2期

关键词：

ARTHRITIS; SUPEROXIDE ANION;

D O I：

10.1007/BF02014303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilage destruction in arthritis-related disorders. Human recombinant superoxide dismutase (SOD) blocked IL-1-mediated cartilage destruction but had no effect on IL-1-mediated changes in glycosaminoglycan and prostaglandin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.

引用

页码：71 / 73

页数：3

共 7 条

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