THE TETRAHYDROPYRANYL GROUP AS A CHIRAL AUXILIARY FOR THE NUCLEOPHILIC-ADDITION TO ALPHA-ALKOXY KETONES

被引：14

作者：

CHARETTE, AB

BENSLIMANE, AF

MELLON, C

机构：

[1] Departement de chinue, Université de Montréal, Montréal

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 47期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0040-4039(95)01899-S

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The protected 2-hydroxytetrahydropyranyl group is an efficient chiral auxiliary for the stereoselective nucleophilic addition of Grignard reagents to alpha-alkoxy ketones. We also report that allylSnBu(3)MgBr(2) . OEt(2) is a very efficient system for the chelation controlled stereoselective addition of the allyl group to alpha-alkoxy ketones.

引用

收藏

页码：8557 / 8560

页数：4

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