SITE-DIRECTED MUTAGENESIS AS A PROBE OF ENZYME STRUCTURE AND CATALYSIS - TYROSYL-TRANSFER RNA-SYNTHETASE CYSTEINE-35 TO GLYCINE-35 MUTATION

被引:279
作者
WILKINSON, AJ
FERSHT, AR
BLOW, DM
WINTER, G
机构
[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND
[2] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT PHYS,LONDON SW7 2AY,ENGLAND
[3] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND
关键词
D O I
10.1021/bi00284a007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:3581 / 3586
页数:6
相关论文
共 32 条
[1]   CONSERVED CYSTEINE AND HISTIDINE-RESIDUES IN THE STRUCTURES OF THE TYROSYL AND METHIONYL-TRANSFER RNA-SYNTHETASES [J].
BARKER, DG ;
WINTER, G .
FEBS LETTERS, 1982, 145 (02) :191-193
[2]   TYROSYL-TRANSFER RNA-SYNTHETASE FORMS A MONONUCLEOTIDE-BINDING FOLD [J].
BHAT, TN ;
BLOW, DM ;
BRICK, P ;
NYBORG, J .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 158 (04) :699-709
[3]   PURIFICATION AND PHYSICAL CHARACTERIZATION OF TYROSYL RIBONUCLEIC ACID SYNTHETASES FROM ESCHERICHIA COLI AND BACILLUS SUBTILIS [J].
CALENDAR, R ;
BERG, P .
BIOCHEMISTRY, 1966, 5 (05) :1681-&
[4]  
Crampton M., 1974, CHEM THIOL GROUP, P379
[5]   OLIGONUCLEOTIDE-DIRECTED MUTAGENESIS AS A GENERAL AND POWERFUL METHOD FOR STUDIES OF PROTEIN FUNCTION [J].
DALBADIEMCFARLAND, G ;
COHEN, LW ;
RIGGS, AD ;
MORIN, C ;
ITAKURA, K ;
RICHARDS, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (21) :6409-6413
[6]   NEUTRON-SCATTERING STUDIES OF ESCHERICHIA-COLI TYROSYL-TRANSFER RNA-SYNTHETASE AND OF ITS INTERACTION WITH TRANSFER RNATYR [J].
DESSEN, P ;
ZACCAI, G ;
BLANQUET, S .
JOURNAL OF MOLECULAR BIOLOGY, 1982, 159 (04) :651-664
[7]  
Fersht A. R., 1977, ENZYME STRUCTURE MEC
[8]   DEMONSTRATION OF 2 ACTIVE-SITES ON A MONOMERIC AMINOACYL-TRANSFER-RNA SYNTHETASE - POSSIBLE ROLES OF NEGATIVE COOPERATIVITY AND HALF-OF-SITES REACTIVITY IN OLIGOMERIC ENZYMES [J].
FERSHT, AR .
BIOCHEMISTRY, 1975, 14 (01) :5-12
[9]   DEMONSTRATION OF 2 REACTION PATHWAYS FOR AMINOACYLATION OF TRANSFER-RNA - APPLICATION OF PULSED QUENCHED FLOW TECHNIQUE [J].
FERSHT, AR ;
JAKES, R .
BIOCHEMISTRY, 1975, 14 (15) :3350-3356
[10]   LIGAND-BINDING AND ENZYMIC CATALYSIS COUPLED THROUGH SUBUNITS IN TYROSYL-TRANSFER-RNA SYNTHETASE [J].
FERSHT, AR ;
MULVEY, RS ;
KOCH, GLE .
BIOCHEMISTRY, 1975, 14 (01) :13-18