INCREASED SPECTRIN PROTEOLYSIS IN THE BRINDLED MOUSE-BRAIN

被引：15

作者：

SEUBERT, P ^{[1
]}

PETERSON, C ^{[1
]}

VANDERKLISH, P ^{[1
]}

COTMAN, C ^{[1
]}

LYNCH, G ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717

来源：

NEUROSCIENCE LETTERS | 1990年 / 108卷 / 03期

关键词：

Calcium; Calpain; Copper; Cytoskeleton; N-Methyl-d-aspartate receptor; Neurodegeneration;

D O I：

10.1016/0304-3940(90)90658-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Proteolytically generated fragments of the microfilament anchoring protein brain spectrin were found to accumulate in brindled mouse brain. Proteolysis was most extensive in brain regions possessing high concentrations of N-methyl-d-aspartate (NMDA) receptors (e.g. cortex, striatum, hippocampus). The brindle mutation affects copper homeostasis and thus a variety of copper-dependent enzymes needed in intermediary metabolism. The altered mitochondria of these mice are suggested to less efficiently buffer NMDA receptor-gated calcium fluxes, thus promoting activation of calcium-activated proteases and subsequent degradation of the spectrin meshwork. © 1990.

引用

页码：303 / 308

页数：6

共 20 条

[1] ENTORHINAL CORTEX LESIONS INDUCE A DECREASED CALCIUM-TRANSPORT IN HIPPOCAMPAL MITOCHONDRIA [J].