THE EFFECT OF SUCCESSFUL RENAL-TRANSPLANTATION ON HORMONAL STATUS OF FEMALE RECIPIENTS

被引：16

作者：

KOUTSIKOS, D

SARANDAKOU, A

AGROYANNIS, B

TZANATOS, H

TSOUTSOS, D

KONSTADINIDOU, I

PHOCAS, I

机构：

[1] Nephrological Center, Aretaleon University Hospital, Athens

[2] Hormonological Laboratory, Aretaleon University Hospital, Athens

来源：

RENAL FAILURE | 1990年 / 12卷 / 02期

关键词：

D O I：

10.3109/08860229009087130

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The pituitary, thyroid, and ovarian hormone levels were measured by enzyme and fluorescence polarization immunoassays in 18 women with successful renal transplants (recipients): 10 menstruating, mean age 34.7 years, mean time after transplantation (Tx) 112.00 months, mean SCr 130.60 μmol/L; and 8 menopausal, mean age 52.7 years, mean time after Tx 61.00 months, and mean SCr 119.00 μmol/L. Five women of the menstruating group conceived 7 times and gave birth to 4 healthy infants. The findings were compared to 30 age-matched healthy subjects (controls) and to 13 women under chronic hemodialysis (hemodialyzedpatients): 2 menstruating, 24 and 36 years old, and 11 menopausal, mean age 59.4 years. Serum prolactin (PRL) showed a highly significant increase in hemodialyzed patients (p < 0001) compared to controls. In recipients, PRL levels were significantly lower than in hemodialyzed patients, but higher than in controls (p < 0001). LH and FSH were elevated in menstruating hemodialyzed patients (p < 0001, p < 02, respectively) and significantly high in menopausal hemodialyzed patients (p < 02, p < 01, respectively). In menstruating recipients, LH was also highly elevated (p < 001), while FSH showed no significant difference from controls. In menopausal recipients the increase of LH was less prominent (p < 02) but FSH was highly increased (p < 001). T3, T4, and FTI were absolutely normal in recipients, while they were significantly lower than normal (p < 0001) in hemodialyzed patients. Estradiol showed no significant difference in both groups of recipients, as well as in menopausal hemodialyzed patients. In conclusion, it seems that after successful renal Tx in females, thyroid function is absolutely restored, PEL secretion is almost normalized, gonadotropin secretion is ameliorated in menstruating women, and estradiol secretion is restored. Thus, the restoration of fertility in the menstruating group could be attributed to the normal gonadal and ameliorated gonadotropin secretion. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：125 / 132

页数：8

共 35 条

[1]

Yatzidis H., Improved method for determination of true creatinine, Clin Chem, 28, (1982)

[2]

Lim V.S., Kathpalia S.C., Frohman L.A., Hyperprolactinemia and impaired pituitary response to suppression and stimulation in chronic renal failure: reversal after transplantation, J Clin Endocrinol, 48, pp. 101-107, (1979)

[3]

Handelsman D.J., McDowell I.F.W., Caterson I.D., Tiller D.J., Hall B.M., Turtle J.R., Ovarian function after renal transplantation: comparison of cyclosporin A with azathioprine and prednisone combination regimes, Br J Obstet Gynecol, 91, pp. 802-807, (1984)

[4]

Ferraris J.R., Domene H.M., Escobar M.E., Calletti M.G., Ramirez J.A., Rivarola M.A., Hormonal profile in pubertal females with chronic renal failure: before and under hemodialysis and after renal transplantation, Acta Endocrinol (Copenh), 115, pp. 289-296, (1987)

[5]

Rudolf K., Kunkel S., Rudolf H., Falkenhagen D., Rueting M., Basale und TRH stimulierte TSH-Sekretion sowie Bestimmung von Gesamtthyroxin (T4). Thyroxin-Bindungskapazitaet (TBC) und Freiem Thyroxin-Index (FT4-I) bei Pakientinnen mit chronischer Uraemie, Zentralbl Gynakol, 110, pp. 689-692, (1988)

[6]

Rudolf K., Kunkel S., Rudolf H., Falkenhagen D., Rueting M., Basale und Gondadotropin-Releasinghormone stimulierte Gonadotropin-sekretion bei Patientinnen it chronischer Uraemie, Zentralbl Gynakol, 110, pp. 683-688, (1988)

[7]

Ramirez G., Jubiz W., Gutch C.F., Et al., Thyroid function in chronic renal failure: effects of hemodialy sis, Trans Am Soc Artif Intern Organs, 18, pp. 244-247, (1972)

[8]

Silverberg D.S., Ulan R.A., Fawcett D.M., Dossefor J.B., Grace M., Bettchez K., Effects of chronic hemodialysis on thyroid function in chronic renal failure, Can Med Assoc, 109, pp. 282-286, (1974)

[9]

Ramirez G., O'Neill W.M., Jubiz W., Bloomer H.A., Thyroid dysfunction in uremia: evidence for thyroid and hypophyseal abnormalities, Ann Intern Med Jr, 84, pp. 672-676, (1976)

[10]

Lim V.S., Fang V.S., Katz A.I., Refetoff S., Thyroid dysfunction in chronic renal failure, J Clin Invest, 60, pp. 522-534, (1977)

← 1 2 3 4 →