DIRECT INVITRO AND INVIVO MONITORING OF DESTRUXINS METABOLISM IN INSECTS USING INTERNAL SURFACE REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY .1. BEHAVIOR OF E-DESTRUXIN IN LOCUSTS

被引：23

作者：

CHERTON, JC

LANGE, C

MULHEIM, C

PAIS, M

CASSIER, P

VEY, A

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91190 GIF SUR YVETTE,FRANCE

[2] UNIV PARIS 06,EVOLUT ETRES ORGANISES LAB,F-75006 PARIS,FRANCE

[3] CNRS,URA 11840,INRA,STN RECH PATHOL COMPAREE,F-30380 ST CHRISTOL ALES,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 566卷 / 02期

关键词：

D O I：

10.1016/0378-4347(91)80268-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High-performance liquid chromatography with internal surface reversed-phase packing provides an analytical tool for studying the in vitro and in vivo metabolism of A and E destruxins in the haemolymph and various organs of male adults of Locusta migratoria. A slight amount of injected E destruxin is shown to be hydrated into E-diol destruxin in the haemolymph. The rest of the toxin is recovered unchanged in the fat-body, pericardial tissues and Malpighian tubules, and some further E-diol destruxin formation occurs in these organs. Because E-diol destruxin is only weakly toxic, this appears to be a detoxication process.

引用

页码：511 / 524

页数：14

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