AN INVESTIGATION OF THE ELECTRONIC-STRUCTURE OF THE ANTITUMOR DRUG ELLIPTICINE AND ITS DERIVATIVES .2. SPECTROSCOPIC INDO CI STUDY

被引：5

作者：

DANTAS, SO

GALVAO, DS

机构：

[1] Institute de Física Gleb Wataghin, UNICAMP, CP 6165

来源：

JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM | 1992年 / 257卷 / 3-4期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/0166-1280(92)85054-O

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Ellipticine and its derivatives are molecules that show antitumour and cytotoxic activity, with a multimodal mechanism of action. In this paper we report a spectroscopic intermediate neglect of differential overlap with configuration interaction study of ellipticine and some of its derivatives, in the neutral and charged states. A mechanism that could improve the antitumoural and cytotoxic activity of these compounds is proposed.

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页码：437 / 449

页数：13

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