A PNA-DNA LINKER SYNTHESIS OF N-((4,4'-DIMETHOXYTRITYLOXY)ETHYL)-N-(THYMIN-1-YLACETYL)GLYCINE

被引：41

作者：

PETERSEN, KH

JENSEN, DK

EGHOLM, M

NIELSEN, PE

BUCHARDT, O

机构：

[1] UNIV COPENHAGEN,PANUM INST,DEPT MED BIOCHEM & GENET,LAB B,DK-2200 COPENHAGEN N,DENMARK

[2] UNIV COPENHAGEN,HC ORSTED INST,CTR BIOMOLEC RECOGNIT,DK-2100 COPENHAGEN O,DENMARK

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 11期

关键词：

D O I：

10.1016/0960-894X(95)00177-U

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-(2-benzyloxyethyl)-N-(thymin-1-ylacetyl)glycine was synthesised and used as a linker for coupling DNA and PNA together. Three different 10-mers composed of 6 DNA units and 4 PNA thymine units were made. The PNA-DNA chimera hybridise to complementary DNA or PNA oligomers, and both the PNA and the DNA part of the chimera are involved in the binding.

引用

页码：1119 / 1124

页数：6

共 9 条

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