DEVELOPMENT OF ARTIFICIAL RED-CELLS (ARC) PRODUCED BY GAMMA-RAY INDUCED POLYMERIZATION OF LIPOSOMES

被引：5

作者：

AKAMA, K ^{[1
]}

AWAI, K ^{[1
]}

TOKUYAMA, S ^{[1
]}

SATOH, T ^{[1
]}

HOSOI, F ^{[1
]}

OMICHI, H ^{[1
]}

机构：

[1] JAPAN ATOM ENERGY RES INST,TAKASAKI RADIAT CHEM RES ESTAB,TAKASAKI,GUMMA 37012,JAPAN

来源：

RADIATION PHYSICS AND CHEMISTRY | 1995年 / 46卷 / 02期

关键词：

D O I：

10.1016/0969-806X(95)00021-O

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Artificial red cells (ARC) are prepared by encapsulating Hb with a polymerizable phospholipid. The polymerization of the vesicles were carried out with the irradiation of gamma-rays. The irradiated ARC are physically more stable than any other known liposome type blood substitutes. Because of this stability, they can be easily stored under frozen condition for a long time. No significant changes were observed in vivo study with rats in which ARC were injected intravenously. The oxygen transport capacity of ARC was similar to that of native red blood cells.

引用

页码：257 / 262

页数：6

共 8 条

[1]

AKAMA K, 1992, KOUBUNSHI GAKKAI YOK, V41, P3532

[2]

CHANG TMS, BIOMATER ARTIF CELLS, V20

[3]

DJORDJEVICH L, 1980, EXP HEMATOL, V8, P584

[4] STABILITY AND BLOOD COMPATIBILITY OF POLYLIPID/HB [J].

MORIZAWA, K ;

AKAMA, K ;

KAWAKAMI, Y ;

TSUCHIDA, E .

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY, 1992, 20 (2-4) :641-645

[5]

Satoh T, 1992, ASAIO J, V38, pM580, DOI 10.1097/00002480-199207000-00102

[6]

TOKUYAMA S, 1992, Japanese Journal of Artificial Organs, V21, P309

[7]

WANG L, 1992, POLYM ADVAN TECHNOL, V3, P17

[8]

WANG L, 1992, POLYM ADVAN TECHNOL, V4, P8

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