DEFECTIVE INTERFERING PARTICLES OF HUMAN PARAINFLUENZA VIRUS TYPE-3 ARE ASSOCIATED WITH PERSISTENT INFECTION IN CELL-CULTURE

被引：17

作者：

MOSCONA, A

机构：

[1] Department of Pediatrics, Mount Sinai School of Medicine, New York

来源：

VIROLOGY | 1991年 / 183卷 / 02期

关键词：

D O I：

10.1016/0042-6822(91)91018-C

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

CV-1 cell lines persistently infected with human parainfluenza virus type 3 (HPF3) contain one or more distinct subgenomic RNAs in addition to standard viral genomes. These RNAs are shown to be the genomes of defective-interfering (DI) particles of the virus; they are present in particles in the culture fluid, and they interfere with the growth of wild-type virus. Removal of the particles from the culture fluid by ultracentrifugation yields a supernatant fluid free from inhibitory activity, demonstrating that the anti-viral effect is not mediated by soluble factors. A role for the DI particles in persistence of HPF3 is considered. © 1991.

引用

页码：821 / 824

页数：4

共 24 条

[1] PARAMYXOVIRUS ANTIGENS IN OSTEOCLASTS FROM PAGET BONE TISSUE DETECTED BY MONOCLONAL-ANTIBODIES [J].