MOLECULAR RECOGNITION OF IMMUNOPHILINS AND IMMUNOPHILIN-LIGAND COMPLEXES

被引:41
作者
SCHREIBER, SL
LIU, J
ALBERS, MW
ROSEN, MK
STANDAERT, RF
WANDLESS, TJ
SOMERS, PK
机构
[1] Department of Chemistry, Harvard University, Cambridge, MA 02138
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0040-4020(01)88520-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Immunophilin-ligand complexes have been used to identify a previously unknown step in Ca2+-dependent signal transduction pathways. This Report, which we dedicate to Professor Harry H. Wasserman, describes structural and mechanistic aspects of immunophilin research.
引用
收藏
页码:2545 / 2558
页数:14
相关论文
共 27 条
  • [1] PROBING IMMUNOSUPPRESSANT ACTION WITH A NONNATURAL IMMUNOPHILIN LIGAND
    BIERER, BE
    SOMERS, PK
    WANDLESS, TJ
    BURAKOFF, SJ
    SCHREIBER, SL
    [J]. SCIENCE, 1990, 250 (4980) : 556 - 559
  • [2] 2 DISTINCT SIGNAL TRANSMISSION PATHWAYS IN LYMPHOCYTES-T ARE INHIBITED BY COMPLEXES FORMED BETWEEN AN IMMUNOPHILIN AND EITHER FK506 OR RAPAMYCIN
    BIERER, BE
    MATTILA, PS
    STANDAERT, RF
    HERZENBERG, LA
    BURAKOFF, SJ
    CRABTREE, G
    SCHREIBER, SL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (23) : 9231 - 9235
  • [3] DUMONT FJ, 1990, J IMMUNOL, V144, P251
  • [4] CYCLOSPORINE-A SPECIFICALLY INHIBITS FUNCTION OF NUCLEAR PROTEINS INVOLVED IN T-CELL ACTIVATION
    EMMEL, EA
    VERWEIJ, CL
    DURAND, DB
    HIGGINS, KM
    LACY, E
    CRABTREE, GR
    [J]. SCIENCE, 1989, 246 (4937) : 1617 - 1620
  • [5] NMR-STUDIES OF [U-C-13]CYCLOSPORIN-A BOUND TO CYCLOPHILIN - BOUND CONFORMATION AND PORTIONS OF CYCLOSPORINE INVOLVED IN BINDING
    FESIK, SW
    GAMPE, RT
    EATON, HL
    GEMMECKER, G
    OLEJNICZAK, ET
    NERI, P
    HOLZMAN, TF
    EGAN, DA
    EDALJI, R
    SIMMER, R
    HELFRICH, R
    HOCHLOWSKI, J
    JACKSON, M
    [J]. BIOCHEMISTRY, 1991, 30 (26) : 6574 - 6583
  • [6] NUCLEAR-ASSOCIATION OF A T-CELL TRANSCRIPTION FACTOR BLOCKED BY FK-506 AND CYCLOSPORINE-A
    FLANAGAN, WM
    CORTHESY, B
    BRAM, RJ
    CRABTREE, GR
    [J]. NATURE, 1991, 352 (6338) : 803 - 807
  • [7] FRANCAVILLA A, IN PRESS HEPATOLOGY
  • [8] RAPAMYCIN AND FK506 BINDING-PROTEINS (IMMUNOPHILINS)
    FRETZ, H
    ALBERS, MW
    GALAT, A
    STANDAERT, RF
    LANE, WS
    BURAKOFF, SJ
    BIERER, BE
    SCHREIBER, SL
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (04) : 1409 - 1411
  • [9] 2 CYTOPLASMIC CANDIDATES FOR IMMUNOPHILIN ACTION ARE REVEALED BY AFFINITY FOR A NEW CYCLOPHILIN - ONE IN THE PRESENCE AND ONE IN THE ABSENCE OF CSA
    FRIEDMAN, J
    WEISSMAN, I
    [J]. CELL, 1991, 66 (04) : 799 - 806
  • [10] CYCLOPHILIN - A SPECIFIC CYTOSOLIC BINDING-PROTEIN FOR CYCLOSPORIN-A
    HANDSCHUMACHER, RE
    HARDING, MW
    RICE, J
    DRUGGE, RJ
    [J]. SCIENCE, 1984, 226 (4674) : 544 - 547