AN ATYPICAL CARCINOID-TUMOR OF THE LUNG WITH MUTATIONS IN THE P53 GENE AND THE RETINOBLASTOMA GENE

被引:10
作者
HIYAMA, K [1 ]
HASEGAWA, K [1 ]
ISHIOKA, S [1 ]
TAKAHASHI, N [1 ]
YAMAKIDO, M [1 ]
机构
[1] RADIAT EFFECTS RES FDN,DEPT GENET,HIROSHIMA 730,JAPAN
关键词
D O I
10.1378/chest.104.5.1606
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Molecular analysis of a metastatic lesion of an atypical carcinoid tumor of the lung obtained from a 77-year-old man at autopsy revealed a point mutation in the p53 gene and a deletion in the retinoblastoma (Rb) mRNA. This case suggests that both these antioncogenes may be involved in the progression of atypical carcinoid tumor.
引用
收藏
页码:1606 / 1607
页数:2
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