SUPRABASAL INTEGRIN EXPRESSION IN THE EPIDERMIS OF TRANSGENIC MICE RESULTS IN DEVELOPMENTAL DEFECTS AND A PHENOTYPE RESEMBLING PSORIASIS

Integrin expression is normally confined to the basal layer of the epidermis, but when epidermal homeostasis is perturbed, the receptors are also expressed by suprabasal, differentiating keratinocytes. We have used the involucrin promoter to express functional human integrin subunits alpha(2), alpha(5), and beta(1) in the suprabasal epidermal layers of transgenic mice. In mice expressing alpha(5) or beta(1) alone or alpha(2) beta(1) or alpha(5) beta(1) heterodimers, there were hair and whisker abnormalities and a failure of eyelid fusion. In addition, mice expressing beta(1) alone or in combination with an or as exhibited epidermal hyperproliferation, perturbed keratinocyte differentiation, and skin inflammation, all of which are features of a common human skin disease, psoriasis.