MESOTELENCEPHALIC DOPAMINE SYSTEM AND REPRODUCTIVE-BEHAVIOR IN THE FEMALE RAT - EFFECTS OF VENTRAL TEGMENTAL 6-HYDROXYDOPAMINE LESIONS ON MATERNAL AND SEXUAL RESPONSIVENESS

被引：161

作者：

HANSEN, S ^{[1
]}

HARTHON, C ^{[1
]}

WALLIN, E ^{[1
]}

LOFBERG, L ^{[1
]}

SVENSSON, K ^{[1
]}

机构：

[1] GOTHENBURG UNIV, DEPT PHARMACOL, S-41124 GOTHENBURG, SWEDEN

来源：

BEHAVIORAL NEUROSCIENCE | 1991年 / 105卷 / 04期

关键词：

D O I：

10.1037/0735-7044.105.4.588

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of lesions to the mesolimbic dopamine system on maternal and sexual behaviors in the female rat was assessed. Rat dams that were given ventral tegmental area microinfusions of 6-hydroxydopamine (6-OHDA) during lactation showed a persistent deficit in pup retrieval but were not impaired with respect to nursing, nest building, or maternal aggression. In addition, 6-OHDA-lesioned females failed to respond to amphetamine by showing locomotor hyperactivity. Administration of the dopamine blocker raclopride to neurologically intact dams also inhibited pup retrieval but had no effect on nursing. Females given 6-OHDA during pregnancy appeared completely unresponsive to pups, whereas no maternal deficits were seen in females that received 6-OHDA 8 weeks before parturition. Proceptive (hopping and darting) and receptive (lordosis) components of sexual behavior, assessed after ovariectomy and exogenous steroid hormone treatment, were not affected by mesolimbic 6-OHDA lesions.

引用

页码：588 / 598

页数：11

共 79 条

[1] HYPERACTIVITY OF REMAINING DOPAMINERGIC NEURONS AFTER PARTIAL DESTRUCTION OF NIGRO-STRIATAL DOPAMINERGIC SYSTEM IN RAT [J].

AGID, Y ;

JAVOY, F ;

GLOWINSKI, J .

NATURE-NEW BIOLOGY, 1973, 245 (144) :150-151

[2] IMPORTANCE OF CENTRAL CATECHOLAMINES IN MEDIATION OF LORDOSIS BEHAVIOR IN OVARIECTOMIZED RATS TREATED WITH ESTROGEN AND INHIBITORS OF MONOAMINE SYNTHESIS [J].

AHLENIUS, S ;

ENGEL, J ;

ERIKSSON, H ;

MODIGH, K ;

SODERSTEN, P .

JOURNAL OF NEURAL TRANSMISSION, 1972, 33 (04) :247-255

[3] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375

[4] SEXUAL ATTRACTIVITY, PROCEPTIVITY, AND RECEPTIVITY IN FEMALE MAMMALS [J].

BEACH, FA .

HORMONES AND BEHAVIOR, 1976, 7 (01) :105-138

[5] DOPAMINE AND PREPARATORY BEHAVIOR .2. A NEUROCHEMICAL ANALYSIS [J].

BLACKBURN, JR ;

PHILLIPS, AG ;

JAKUBOVIC, A ;

FIBIGER, HC .

BEHAVIORAL NEUROSCIENCE, 1989, 103 (01) :15-23

[6] DOPAMINE AND PREPARATORY BEHAVIOR .1. EFFECTS OF PIMOZIDE [J].

BLACKBURN, JR ;

PHILLIPS, AG ;

FIBIGER, HC .

BEHAVIORAL NEUROSCIENCE, 1987, 101 (03) :352-360

[7] RAPID CHANGES IN STRIATAL ASCORBATE IN RESPONSE TO TAIL-PINCH MONITORED BY CONSTANT POTENTIAL VOLTAMMETRY [J].

BOUTELLE, MG ;

SVENSSON, L ;

FILLENZ, M .

NEUROSCIENCE, 1989, 30 (01) :11-17

[8]

Brown R.E., 1979, Advances in the Study of Behavior, V10, P103, DOI 10.1016/S0065-3454(08)60094-7

[9] DISSOCIATION OF ACTIVE FROM IMMOBILITY COMPONENTS OF SEXUAL-BEHAVIOR IN FEMALE RATS BY CENTRAL 6-HYDROXY-DOPAMINE - IMPLICATIONS FOR CA INVOLVEMENT IN SEXUAL-BEHAVIOR AND SENSORIMOTOR RESPONSIVENESS [J].

CAGGIULA, AR ;

HERNDON, JG ;

SCANLON, R ;

GREENSTONE, D ;

BRADSHAW, W ;

SHARP, D .

BRAIN RESEARCH, 1979, 172 (03) :505-520

[10]

CAGGIULA AR, 1979, CATECHOLAMINES BASIC, P1765

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