INCREASED RESISTANCE AGAINST OXIDATIVE STRESS IS OBSERVED DURING A SHORT-PERIOD OF RENAL REPERFUSION AFTER A TEMPORAL ISCHEMIA

被引：4

作者：

CAMPOS, R ^{[1
]}

GARRIDO, A ^{[1
]}

GUERRA, R ^{[1
]}

VALENZUELA, A ^{[1
]}

机构：

[1] UNIV CHILE,INST NUTR & TECNOL ALIMENTOS,UNIDAD BIOQUIM FARMACOL,CASILLA 13811,SANTIAGO,CHILE

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1990年 / 10卷 / 4-5期

关键词：

Ischaemia-reperfusion damage; Microsomal free radicals; Renal ischaemia; Tissue oxidative damage;

D O I：

10.3109/10715769009149894

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reperfusion of rat kidney submitted to temporal ischaemia induces a decrease in glutathione content. Lipid peroxidation is not detected in kidney homogenates but microsomes obtained after periods of reperfusion longer than 60 minutes show increased malondialdehyde values correlated with high oxygen consumption and superoxide free radical generation. Microsomes obtained from kidneys submitted to 15 or 60 minutes of reperfusion are resistant to NADPH-induced lipid peroxidation but after 120 minutes of reperfusion an increased lipid peroxidative response is observed. Although the mechanism of the protection found in microsomes against the induction of oxidative stress in the first 60 minutes of reperfusion is unknown, it is postulated that this subcellular fraction plays an important role in the oxidative stress observed after longer periods of reperfusion. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：259 / 264

页数：6

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