CONFORMATION OF VINBLASTINE IN AQUEOUS-SOLUTION DETERMINED BY 2D H-1-NMR AND C-13-NMR SPECTROSCOPY

被引：12

作者：

GAGGELLI, E

VALENSIN, G

STOLOWICH, NJ

WILLIAMS, HJ

SCOTT, AI

机构：

[1] TEXAS A&M UNIV SYST,CTR BIOL NUCL MAGNET RESONANCE,COLLEGE STN,TX 77843

[2] UNIV SIENA,DEPT CHEM,I-53100 SIENA,ITALY

[3] UNIV BASILICATA,INST CHEM,I-85100 POTENZA,ITALY

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 03期

关键词：

D O I：

10.1021/np50081a002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The conformation of vinblastine [1] in H2O solution at pD in the range 4.8-6.6 has been delineated by interpreting H-1-nmr 2D COSY and NOESY maps, H-1-C-13 2D correlated spectra, and the pattern of proton-proton scalar couplings. A molecular model of the preferred spatial arrangement has been obtained and compared with the structure previously determined in organic solvents. The dihedral angle between the two indole moieties has been evaluated at ca. 180-degrees as compared to the value of 160-degrees in organic solution.

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页码：285 / 293

页数：9

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