THE ROLE OF INTEGRINS IN GRANULOCYTE DYSFUNCTION IN MYELODYSPLASTIC SYNDROME

被引：17

作者：

RICEVUTI, G ^{[1
]}

MAZZONE, A ^{[1
]}

PASOTTI, D ^{[1
]}

FOSSATI, G ^{[1
]}

MAZZUCCHELLI, I ^{[1
]}

NOTARIO, A ^{[1
]}

机构：

[1] UNIV PAVIA, POLICLIN SAN MATTEO,IRCCS, DEPT INTERNAL MED & THERAPEUT,MED PATHOL SECT, I-27100 PAVIA, ITALY

来源：

LEUKEMIA RESEARCH | 1993年 / 17卷 / 07期

关键词：

CD11/CD18; FLOW CYTOMETER; IMAGE ANALYSIS; GRANULOCYTES; INTEGRINS; MYELODYSPLASTIC SYNDROMES; MONOCLONAL ANTIBODIES;

D O I：

10.1016/0145-2126(93)90092-Y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of the present study was to evaluate the function of granulocytes in 20 patients affected by myelodysplastic syndrome (MDS) and correlate this with the expression of surface membrane integrins. The granulocytes showed a deficit in chemotaxis (34 +/- 12 vs 84 +/- 10, p < 0.01) in superoxide release (12 +/- 7 vs 30 +/- 10, p < 0.01) and in aggregation (12 +/- 6 vs 36 +/- 9, p < 0.01 using fMLP as stimulus. We also demonstrated with cytofluorimetric and alkaline phosphatase immunoenzymatic analysis (APAAP), decreased expression of CD11b/CD18 receptor detected by OKM1 (p < 0.001) and CD18 detected by MoAb IOT-18 (p < 0.001). PMNs CD11b/CD18 up-regulation and APAAP image analysis studies showed a lower level of expression of CD11b/CD18 in granulocytes from MDS patients compared to controls (p < 0.001). We concluded that granulocyte dysfunction in MDS may be correlated with modification of leukocyte integrins.

引用

页码：609 / 619

页数：11

共 58 条

[1]

ARNAOUT MA, 1990, BLOOD, V75, P1037

[2] DEFICIENCY OF A LEUKOCYTE SURFACE GLYCOPROTEIN (LFA-1) IN 2 PATIENTS WITH MO1 DEFICIENCY - EFFECTS OF CELL ACTIVATION ON MO1 LFA-1 SURFACE EXPRESSION IN NORMAL AND DEFICIENT LEUKOCYTES [J].