ISOLATION OF A DROSOPHILA GENE ENCODING A HEAD-SPECIFIC GUANYLYL CYCLASE

被引：23

作者：

YOSHIKAWA, S ^{[1
]}

MIYAMOTO, I ^{[1
]}

ARUGA, J ^{[1
]}

FURUICHI, T ^{[1
]}

OKANO, H ^{[1
]}

MIKOSHIBA, K ^{[1
]}

机构：

[1] UNIV TOKYO,INST MED SCI,DEPT MOLEC NEUROBIOL,4-6-1 SHIROKANEDAI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF NEUROCHEMISTRY | 1993年 / 60卷 / 04期

关键词：

GUANYLYL CYCLASE; DROSOPHILA DGC1 GENE; CNS; PHOTOTRANSDUCTION;

D O I：

10.1111/j.1471-4159.1993.tb03324.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and characterized a new guanylyl cyclase gene (dgc1) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian soluble-type guanylyl cyclase a subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgc1 mRNA was detected in wild-type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgc1 is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgc1 may have a role in phototransduction.

引用

页码：1570 / 1573

页数：4

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