STUDIES ON HEMOLYTIC ACTION OF A HEMOLYSIN PRODUCED BY VIBRIO-MIMICUS

被引：36

作者：

SHINODA, S ^{[1
]}

ISHIDA, K ^{[1
]}

OH, EG ^{[1
]}

SASAHARA, K ^{[1
]}

MIYOSHI, S ^{[1
]}

CHOWDHURY, MAR ^{[1
]}

YASUDA, T ^{[1
]}

机构：

[1] OKAYAMA UNIV,INST CELLULAR & MOLEC BIOL,OKAYAMA 700,JAPAN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1993年 / 37卷 / 05期

关键词：

HEMOLYSIN; VIBRIO-MIMICUS; GANGLIOSIDES;

D O I：

10.1111/j.1348-0421.1993.tb03229.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some properties and mechanism of action of a hemolysin (VMH) produced by an enteropathogenic Vibrio mimicus strain was examined. VMH was heat-labile and inhibited by addition of divalent cations, including Ca2+, Mg2+ and Mn2+. The hemolysis by VMH was inhibited by incubating with gangliosides, suggesting that the ganglioside was the binding site on the erythrocyte membrane for VMH. Existence of a galactose moiety on reducing end of the ganglioside molecule and a sialic acid on the galactose moiety was suggested to be important for the binding of VMH molecule. Colloid osmotic manner of the hemolysis by VMH was demonstrated.

引用

页码：405 / 409

页数：5

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