THE EFFECT OF CROMOLYN SODIUM AND NEDOCROMIL SODIUM ADMINISTERED BY A PRESSURIZED AEROSOL WITH A SPACER DEVICE ON EXERCISE-INDUCED ASTHMA IN CHILDREN

To compare the effectiveness of cromolyn sodium (CS) (10 mg) and nedocromil sodium (NS) (4 mg) administered by a metered dose inhaler (MDI) with a spacer device in preventing exercise-induced asthma (EIA), eight asthmatic children with EIA were studied in randomized double-blind, cross-over, placebo-controlled study. CS and NS provided significant, comparable protection from EIA and both were better than placebo. We conclude that CS and NS administered by a pressurized aerosol with a spacer device provide equal protection against EIA in children.