SYNTHESIS, BIOLOGICAL EVALUATION, AND QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP ANALYSIS OF 2-HYDROXY-1H-ISOINDOLEDIONES AS NEW CYTOSTATIC AGENTS

被引：40

作者：

CHAN, CL

LIEN, EJ

TOKES, ZA

机构：

[1] UNIV SO CALIF,SCH PHARM,LOS ANGELES,CA 90033

[2] UNIV SO CALIF,CTR COMPREHENS CANC,LOS ANGELES,CA 90033

[3] UNIV SO CALIF,SCH MED,LOS ANGELES,CA 90033

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 03期

关键词：

D O I：

10.1021/jm00386a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：509 / 514

页数：6

共 19 条

[1]

ATKIN CL, 1973, J BIOL CHEM, V248, P7464

[2] A SIMPLE ASSESSMENT OF PARTITION DATA FOR CORRELATING STRUCTURE AND BIOLOGICAL ACTIVITY USING THIN-LAYER CHROMATOGRAPHY [J].

BOYCE, CBC ;

MILBORROW, BV .

NATURE, 1965, 208 (5010) :537-+

[3]

BROCKMAN RW, 1970, P SOC EXP BIOL MED, V133, P609, DOI 10.3181/00379727-133-34528

[4]

EHRENBERG A, 1972, J BIOL CHEM, V247, P3485

[5]

Elford H L, 1980, Adv Enzyme Regul, V19, P151, DOI 10.1016/0065-2571(81)90014-5

[6] EFFECT OF HYDROXYUREA ANALOGUES IN REGENERATING RAT LIVER [J].

HILL, RB ;

GORDON, JA .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1968, 9 (01) :71-&

[7]

HURD CD, 1954, J ORG CHEM, V19, P1140

[8] USE OF DIPOLE-MOMENT AS A PARAMETER IN DRUG RECEPTOR INTERACTION AND QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES [J].

LIEN, EJ ;

GUO, ZR ;

LI, RL ;

SU, CT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (06) :641-655

[9]

Remers W., 1984, ANTINEOPLASTIC AGENT

[10]

ROMANELLI MG, 1973, ORGANIC SYNTHESES, V5

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